Table 2.

IC50 values for chlorambucil or fludarabine alone or in the presence of GA

Patient no.
Sex/age, y/stage
Previous treatment
Lymphocyte count, × 109/L
ZAP-70 status
IC50, μM
GA
Chl
Chl/GA, 1000:1
Flu
Flu/GA, 100:1
1   M/72/A   Chl   66.8   Negative   0.61   24.2   23.7   3.3   2.2  
2   M/78/A   None   54.1   Negative   0.17   61.8   13.7*  1.2   0.3* 
3   M/72/A   Chl   66.7   Positive   0.08   167   14.3*  5.4   1.7† 
4   F/75/B   None   47.4   Positive   0.14   68.6   16.3*  3.3   1.6† 
5   M/72/C   Chl/Flu   74.9   Positive   0.11   27.8   9.0†  2.0   0.96† 
6   M/76/C   None   25.9   Positive   0.50   50.9   42.3   7.5   4.8  
7   M/73/B   Chl   30.8   Positive   0.03   8.8   10.4   0.76   0.22† 
8   M/75/A   None   23.6   Negative   0.09   60.5   23.3†  1.2   1.2  
9   M/57/B   None   34.0   Negative   0.01   20.2   7.1†  0.38   0.11† 
10   M/56/B   None   10.9   Positive   0.02   13.2   5.7†  2.6   0.77† 
11   M/49/A   None   24.4   Positive   0.06   13.3   6.5†  1.1   0.75  
12   M/82/C   Chl   81.1   Positive   0.07   10.7   6.1   0.68   0.55  
13   M/83/A   None   43.9   Positive   0.01   5.3   3.6   0.77   0.37  
14   F/63/C   Chl   10.1   Negative   0.68   22.6   21.2   ND   ND  
15   M/66/C   None   20.2   Negative   0.06   20.3   10.1†  0.70   0.25† 
16   M/80/B   None   45.9   Negative   0.03   21.8   7.6†  0.45   0.20† 
17   M/62/B   Chl   41.2   Negative   0.01   18.3   6.9†  0.38   0.47  
18   F/63/C   Chl   108   Positive   0.07   76.4   10.6*  0.87   1.2  
19   F/69/C   Chl   63.0   Negative   0.03   44.4   8.9*  0.81   0.98  
20   F/78/A   None   25.5   Positive   0.04   18   7.7*  0.19   0.18  
21
 		 M/70/A
 		 None
 		 10.6
 		 Negative
 		 0.01
 		 7.1
 		 5.9
 		 ND
 		 ND
 
Patient no.
Sex/age, y/stage
Previous treatment
Lymphocyte count, × 109/L
ZAP-70 status
IC50, μM
GA
Chl
Chl/GA, 1000:1
Flu
Flu/GA, 100:1
1   M/72/A   Chl   66.8   Negative   0.61   24.2   23.7   3.3   2.2  
2   M/78/A   None   54.1   Negative   0.17   61.8   13.7*  1.2   0.3* 
3   M/72/A   Chl   66.7   Positive   0.08   167   14.3*  5.4   1.7† 
4   F/75/B   None   47.4   Positive   0.14   68.6   16.3*  3.3   1.6† 
5   M/72/C   Chl/Flu   74.9   Positive   0.11   27.8   9.0†  2.0   0.96† 
6   M/76/C   None   25.9   Positive   0.50   50.9   42.3   7.5   4.8  
7   M/73/B   Chl   30.8   Positive   0.03   8.8   10.4   0.76   0.22† 
8   M/75/A   None   23.6   Negative   0.09   60.5   23.3†  1.2   1.2  
9   M/57/B   None   34.0   Negative   0.01   20.2   7.1†  0.38   0.11† 
10   M/56/B   None   10.9   Positive   0.02   13.2   5.7†  2.6   0.77† 
11   M/49/A   None   24.4   Positive   0.06   13.3   6.5†  1.1   0.75  
12   M/82/C   Chl   81.1   Positive   0.07   10.7   6.1   0.68   0.55  
13   M/83/A   None   43.9   Positive   0.01   5.3   3.6   0.77   0.37  
14   F/63/C   Chl   10.1   Negative   0.68   22.6   21.2   ND   ND  
15   M/66/C   None   20.2   Negative   0.06   20.3   10.1†  0.70   0.25† 
16   M/80/B   None   45.9   Negative   0.03   21.8   7.6†  0.45   0.20† 
17   M/62/B   Chl   41.2   Negative   0.01   18.3   6.9†  0.38   0.47  
18   F/63/C   Chl   108   Positive   0.07   76.4   10.6*  0.87   1.2  
19   F/69/C   Chl   63.0   Negative   0.03   44.4   8.9*  0.81   0.98  
20   F/78/A   None   25.5   Positive   0.04   18   7.7*  0.19   0.18  
21
 		 M/70/A
 		 None
 		 10.6
 		 Negative
 		 0.01
 		 7.1
 		 5.9
 		 ND
 		 ND
 

Chl indicates chlorambucil; Flu, fludarabine; and ND, not done.

*

Isolates whose IC50 was decreased by more than 75% in the presence of GA.

†

Isolates whose IC50 was decreased by more than 50% in the presence of GA.

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