Engraftment of PHSCs from MI-treated or nonirradiated mice
. | . | Spleen . | . | . | . | ||
|---|---|---|---|---|---|---|---|
| Source . | Bone marrow . | CD4 cells . | CD8 cells . | B cells . | Thymus . | ||
| From legs of non-MI-treated mice, n = 7 | 17.27 ± 12.27 | 9.33 ± 5.97 | 5.00 ± 4.86 | 15.41 ± 8.65 | 7.80 ± 5.56 | ||
| From legs of MI-treated mice, n = 5* | 45.01 ± 11.31 | 34.02 ± 8.30 | 29.71 ± 13.43 | 44.51 ± 16.16 | 35.56 ± 15.77 | ||
| From sternum and vertebrae of MI-treated mice, n = 5* | 49.38 ± 10.64 | 42.24 ± 7.60 | 42.32 ± 8.53 | 54.20 ± 9.90 | 46.42 ± 24.2 | ||
. | . | Spleen . | . | . | . | ||
|---|---|---|---|---|---|---|---|
| Source . | Bone marrow . | CD4 cells . | CD8 cells . | B cells . | Thymus . | ||
| From legs of non-MI-treated mice, n = 7 | 17.27 ± 12.27 | 9.33 ± 5.97 | 5.00 ± 4.86 | 15.41 ± 8.65 | 7.80 ± 5.56 | ||
| From legs of MI-treated mice, n = 5* | 45.01 ± 11.31 | 34.02 ± 8.30 | 29.71 ± 13.43 | 44.51 ± 16.16 | 35.56 ± 15.77 | ||
| From sternum and vertebrae of MI-treated mice, n = 5* | 49.38 ± 10.64 | 42.24 ± 7.60 | 42.32 ± 8.53 | 54.20 ± 9.90 | 46.42 ± 24.2 | ||
BMCs were harvested from long-term chimera 40 weeks after BMT. BMCs (1 × 107) were injected to lethally irradiated (10 Gy) CD45.1 mice. Mice were killed 27 weeks after adoptive transfer. Values are presented as mean % donor cells ± standard deviation.
Significantly higher than non-MI-treated animals (P < .05).