Results of induction therapy for patients with APL
. | . | Study . | . | Age, y . | . | WBC count, × 109/L . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
. | Overall, no. (%) . | LPA96, no. (%) . | LPA99, no. (%) . | 70 y or younger, no. (%) . | Older than 70 y, no. (%) . | Lower than 10, no. (%) . | 10 or higher, no. (%) . | |||
| Complete remission | 384 (90) | 157 (90) | 227 (90) | 369 (92) | 15 (68) | 287 (93) | 97 (84) | |||
| Failure | 42 | 18 | 24 | 35 | 7 | 22 | 20 | |||
| Early death | 39 | 15 | 24 | 33 | 6 | 21 | 18 | |||
| Hemorrhage | 25 (64) | 9 (60) | 16 (67) | 21 (64) | 4 (66) | 12 (57) | 13 (72) | |||
| Infection | 11 (28) | 5 (33) | 6 (25) | 9 (27) | 2 (33) | 7 (33) | 4 (22) | |||
| Retinoic acid syndrome | 2 (5) | 1 (7) | 1 (4) | 2 (6) | 0 | 1 (5) | 1 (6) | |||
| Other | 1 (3) | 0 | 1 (4) | 1 (3) | 0 | 1 (5) | 0 | |||
| Resistance | 3 | 3 | 0 | 2 | 1 | 1 | 2 | |||
| Retinoic acid syndrome | ||||||||||
| Definitely present | 18 (4.2) | 8 (4.6) | 10 (4.0) | 17 | 1 | 10 | 8 | |||
| Indeterminate | 105 (24.6) | 40 (25.9) | 65 (22.9) | 100 | 5 | 72 | 33 | |||
| Definitely absent | 303 | 127 | 176 | 287 | 16 | 227 | 76 | |||
. | . | Study . | . | Age, y . | . | WBC count, × 109/L . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
. | Overall, no. (%) . | LPA96, no. (%) . | LPA99, no. (%) . | 70 y or younger, no. (%) . | Older than 70 y, no. (%) . | Lower than 10, no. (%) . | 10 or higher, no. (%) . | |||
| Complete remission | 384 (90) | 157 (90) | 227 (90) | 369 (92) | 15 (68) | 287 (93) | 97 (84) | |||
| Failure | 42 | 18 | 24 | 35 | 7 | 22 | 20 | |||
| Early death | 39 | 15 | 24 | 33 | 6 | 21 | 18 | |||
| Hemorrhage | 25 (64) | 9 (60) | 16 (67) | 21 (64) | 4 (66) | 12 (57) | 13 (72) | |||
| Infection | 11 (28) | 5 (33) | 6 (25) | 9 (27) | 2 (33) | 7 (33) | 4 (22) | |||
| Retinoic acid syndrome | 2 (5) | 1 (7) | 1 (4) | 2 (6) | 0 | 1 (5) | 1 (6) | |||
| Other | 1 (3) | 0 | 1 (4) | 1 (3) | 0 | 1 (5) | 0 | |||
| Resistance | 3 | 3 | 0 | 2 | 1 | 1 | 2 | |||
| Retinoic acid syndrome | ||||||||||
| Definitely present | 18 (4.2) | 8 (4.6) | 10 (4.0) | 17 | 1 | 10 | 8 | |||
| Indeterminate | 105 (24.6) | 40 (25.9) | 65 (22.9) | 100 | 5 | 72 | 33 | |||
| Definitely absent | 303 | 127 | 176 | 287 | 16 | 227 | 76 | |||
Populations were as follows: overall, n = 426; LPA96, n = 175; and LPA99, n = 251.