Table 3. Changes in T-cell proliferative... | American Society of Hematology

Table 3.

Changes in T-cell proliferative responses to GPIIb/IIIa and tetanus toxoid after a single injection of IDEC-131/E6040

	Stimulation index of antigen-specific T-cell proliferation
IDEC-131/E6040 dose	Day 0 pretreatment	Day 7 after treatment	Day 42 after treatment
GPIIb/IIIa-specific T-cell response
2 mg/kg	2.3 ± 0.8	2.6 ± 1.5	2.2 ± 1.5
5 mg/kg	6.5 ± 4.9	4.6 ± 4.1	2.3 ± 1.2
10 mg/kg	8.3 ± 5.9	4.7 ± 5.1*	3.2 ± 1.0†
Tetanus toxoid-specific T-cell response
2 mg/kg	4.9 ± 2.0	5.0 ± 3.3	3.3 ± 1.9
5 mg/kg	1.9 ± 1.6	1.9 ± 1.5	2.6 ± 2.6
10 mg/kg	4.5 ± 3.2	4.0 ± 2.6	3.5 ± 1.8

	Stimulation index of antigen-specific T-cell proliferation
IDEC-131/E6040 dose	Day 0 pretreatment	Day 7 after treatment	Day 42 after treatment
GPIIb/IIIa-specific T-cell response
2 mg/kg	2.3 ± 0.8	2.6 ± 1.5	2.2 ± 1.5
5 mg/kg	6.5 ± 4.9	4.6 ± 4.1	2.3 ± 1.2
10 mg/kg	8.3 ± 5.9	4.7 ± 5.1*	3.2 ± 1.0†
Tetanus toxoid-specific T-cell response
2 mg/kg	4.9 ± 2.0	5.0 ± 3.3	3.3 ± 1.9
5 mg/kg	1.9 ± 1.6	1.9 ± 1.5	2.6 ± 2.6
10 mg/kg	4.5 ± 3.2	4.0 ± 2.6	3.5 ± 1.8

P = .054 compared with pretreatment by repeated measures analysis of variance.

P = .08 compared with pretreatment by repeated measures analysis of variance.