Table 1.

Association of FLT3 expression with gene mutations


Gene mutations

n

Mean FLT3 transcript level, copies/μgRNA (range)

P
FLT3/ITD   38   30 801 (415-759 110)   .0020  
MLL-TD   19   76 556 (1324-1 731 514)   .0121  
FLT3/D835   8   63 756 (1885-219 489)   .0463  
p53  10   15 888 (15-121 219)   NS  
N-RAS  22   25 171 (19-1 731 514)   NS  
No mutations   101   13 705 (0-2 322 706)   
Total
 
181
 
20 203 (0-2 322706)
 

 

Gene mutations

n

Mean FLT3 transcript level, copies/μgRNA (range)

P
FLT3/ITD   38   30 801 (415-759 110)   .0020  
MLL-TD   19   76 556 (1324-1 731 514)   .0121  
FLT3/D835   8   63 756 (1885-219 489)   .0463  
p53  10   15 888 (15-121 219)   NS  
N-RAS  22   25 171 (19-1 731 514)   NS  
No mutations   101   13 705 (0-2 322 706)   
Total
 
181
 
20 203 (0-2 322706)
 

 

Mean (minimum to maximum) expression levels of the FLT3 transcript are indicated according to the gene mutations. Statistical analysis was performed by comparing the cases harboring each gene mutation with those harboring no mutations. No mutations indicates cases without FLT3/ITD, MLL-TD, FLT3/D835, p53, and N-RAS mutations. NS indicates no significance. Seven cases had both FLT3/ITD and MLL-TD, and two of them had p53 gene mutations. Two cases had both MLL-TD and N-RAS gene mutations.

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