Cause of death in all patients
Cause of death . | Fluconazole (%); n = 148 patients . | Itraconazole (%); n = 151 patients . |
|---|---|---|
| Relapsed malignancy | 9 (6) | 6 (4) |
| Idiopathic pneumonitis* | 8 (5) | 12 (8) |
| Bacterial sepsis or pneumonia | 5 (3) | 14 (9) |
| Fungal infections | 11 (7) | 12 (8) |
| Viral infections† | 4 (3) | 9 (6) |
| Other‡ | 7 (5) | 2 (1) |
Cause of death . | Fluconazole (%); n = 148 patients . | Itraconazole (%); n = 151 patients . |
|---|---|---|
| Relapsed malignancy | 9 (6) | 6 (4) |
| Idiopathic pneumonitis* | 8 (5) | 12 (8) |
| Bacterial sepsis or pneumonia | 5 (3) | 14 (9) |
| Fungal infections | 11 (7) | 12 (8) |
| Viral infections† | 4 (3) | 9 (6) |
| Other‡ | 7 (5) | 2 (1) |
Includes idiopathic pneumonitis, bronchiolitis obliterans—organizing pneumonia, and diffuse alveolar damage/hemorrhage.
Viral infections included diseases caused by cytomegalovirus (n = 7), human herpes virus 6 (n = 3), respiratory viruses (n = 2), and Epstein-Barr virus (n = 1).
Other causes of death included multiorgan failure (n = 3), regimen-related toxicity/venoocclusive disease (n = 2), pulmonary embolism (n = 1), encephalopathy (n = 1), meningitis of unknown etiology (n = 1), and trauma (n = 1).