Table 8.

Plasma pharmacokinetic parameters for each cytokine after intravenous administration of 4F to normal and irradiated monkeys

Pharmacokinetic parameters
SCF
FL
MGDF
IL-3
Unir
After TBI*
Unir
After TBI*
Unir
After TBI*
Unir
After TBI*
Elimination half-life, h   4.2   6.3 ± 1.2   13.2   12.32 ± 4.9   6.15   4.9 ± 0.7   1.35   2.25 ± 1.3  
Clearance, mL/h/kg   25.16   31.7 ± 5.6   4.46   7.75 ± 3.5   3.5   2.1 ± 0.7   70   220.2 ± 60  
Vc, mL/kg   32.43   21.9 ± 2.3   65.52   46.5 ± 16.7   3.6   8.7 ± 3.5   7.2   111.2 ± 31  
Vd, mL/kg   156   288 ± 57   75.95   116.6 ± 45   31.2   15.1 ± 3.3   138.9   723 ± 227  
AUC, μg/mL/h   2   1.73 ± 0.5   9.2   5.48 ± 2.1   13.8   25.4 ± 4.4   0.8   0.27 ± 0.08  
Plasma level at 24 h, ng/mL
 		 2.5
 		 0.65 ± 0.2
 		 215
 		 99.5 ± 45
 		 80.7
 		 87.3 ± 24
 		 < DT
 		 < DT
 
Pharmacokinetic parameters
SCF
FL
MGDF
IL-3
Unir
After TBI*
Unir
After TBI*
Unir
After TBI*
Unir
After TBI*
Elimination half-life, h   4.2   6.3 ± 1.2   13.2   12.32 ± 4.9   6.15   4.9 ± 0.7   1.35   2.25 ± 1.3  
Clearance, mL/h/kg   25.16   31.7 ± 5.6   4.46   7.75 ± 3.5   3.5   2.1 ± 0.7   70   220.2 ± 60  
Vc, mL/kg   32.43   21.9 ± 2.3   65.52   46.5 ± 16.7   3.6   8.7 ± 3.5   7.2   111.2 ± 31  
Vd, mL/kg   156   288 ± 57   75.95   116.6 ± 45   31.2   15.1 ± 3.3   138.9   723 ± 227  
AUC, μg/mL/h   2   1.73 ± 0.5   9.2   5.48 ± 2.1   13.8   25.4 ± 4.4   0.8   0.27 ± 0.08  
Plasma level at 24 h, ng/mL
 		 2.5
 		 0.65 ± 0.2
 		 215
 		 99.5 ± 45
 		 80.7
 		 87.3 ± 24
 		 < DT
 		 < DT
 

Unir indicates unirradiated monkeys (n = 2); after TBI, pharmacokinetic study performed over 24 hours after 4F was administered 2 hours after irradiation (n = 5); and DT, Elisa kit detection threshold.

*

Values given as mean ± SD.

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