Genes regulated by TFPI-2 expression in fibrosarcoma xenografts obtained from SCID mice
GeneBank accession no. . | Fold change* . | Description . |
|---|---|---|
| Transcription factors | ||
| NM_001186 | −2.11 | Helicase, basic leucine zipper transcription factor-1 |
| NM_006963, AA744771 | 29.27 | Zinc finger protein 22 (KOX 15) |
| NM_006291 | 5.05 | Zinc finger protein 185 (LIM domain) |
| NM_014368 | 2.91 | LIM homeobox protein 6 |
| NM_001290 | −5.20 | LIM domain binding 2 |
| NM_002586 | −2.75 | Pre-B-cell leukemia transcription factor-2 (PBX-2) |
| X16155 | −2.79 | COUP-transcription factor |
| Signal transduction | ||
| NM_004445 | −2.38 | Erythropoietin-producing hepatocyte kinase (EphB6) |
| NM_002547 | 2.95 | Oligophrenin 1 |
| NM_002821 | 2.33 | Protein tyrosine kinase 7 |
| U71075 | −2.48 | Protein tyrosine phosphatase, receptor type, U |
| D30751 | 2.79 | Bone morphogenetic protein 4 |
| NM_022159 | −2.92 | EGF-TM-7-latrophilin-related protein |
| Cell growth, proliferation, and maintenance | ||
| NM_013975 | 2.04 | Ligase III, DNA |
| NM_006567 | 2.11 | Phenylalanine-tRNA synthetase |
| AU118882, NM_001957 | −2.90 | Endothelin receptor type A |
| NM_002349 | 14.32 | Lymphocyte antigen 75, gp200-MR6 |
| NM_005330 | −7.63 | Hemoglobin, epsilon 1, oxygen transport |
| NM_000385 | 2.30 | Aquaporin 1 |
| AF052169 | 2.48 | Voltage-gated potassium channel activity |
| BE742268 | −4.21 | Sortilin 1 (SORT 1) |
| AW206786 | −2.32 | Enigma (LIM domain protein) |
| Invasion and metastasis | ||
| M34064 | −2.13 | N-cadherin |
| NM_014751 | 2.06 | Metastasis suppressor gene |
| NM_002961 | 2.79 | S100 calcium-binding protein A4 |
| NM_021111 | 2.64 | Reversion-inducing cysteine-rich protein with kazal motif (RECK) |
| AF348491, AJ224869 | −4.21, −27.40 | Chemokine (C-X-C motif), receptor 4 (fusin) |
| NM_022842 | −18.70 | CUB domain-containing protein 1 (CDCP1) |
| Oncogenes/tumor suppressor genes | ||
| NM_021991 | −2.21 | Junction plakoglobin |
| NM_003287 | 2.10 | Tumor protein D52-like 1 |
| NM_001958 | 6.85 | Eukaryotic translation elongation factor 1 alpha 2 (EEF 1A2) |
| Apoptosis | ||
| NM_005892 | −2.14 | Formin-like (FRL) |
| NM_020371 | −2.11 | Cell death regulator Aven |
| Angiogenesis | ||
| NM_002019 | −2.24 | FLT, VEGFR1, Fms-related tyrosine kinase receptor |
| NM_000584 | −6.99 | Interleukin-8 (IL-8, C-X-CL8) |
| A1812030 | −3.39 | Thrombospondin 1 precursor |
| L01639 | −8.03 | Neuropeptide Y receptor |
| U58111 | −2.41 | Vascular endothelial growth factor C |
| NM_006291 | 2.98 | Tumor necrosis factor, alpha-induced protein 2 |
| Extracellular matrix | ||
| NM_002607 | 2.53 | Platelet-derived growth factor alpha polypeptide |
| NM_021599 | −4.62 | ADAM-TS2 |
| BC002416 | −2.29 | Biglycan |
| NM_000088 | 3.51 | Collagen, type I, alpha 1 |
| AI264196 | −2.48 | Fibrillin 1 precursor |
| D32039 | −2.13 | Chondroitin sulfate proteoglycan 2 (versican) |
| AI146848 | 2.87 | Dermatopontin precursor |
| AJ276395 | −3.80 | Fibronectin 1 |
| AA669336 | 7.26 | Alpha 1 chain of type XII collagen |
| Others | ||
| NM_002759 | 2.51 | EIF2Ak1, protein kinase, PKR |
| NM_004988 | −2.95 | Melanoma antigen family A1 (MAGE-A1) |
| NM_016931 | −2.46 | NADPH oxidase 4 (Nox 4) |
| NM_021822 | 2.80 | Phorbolin-like protein MDS019 |
| NM_001785 | 35.30 | Cytidine deaminase |
GeneBank accession no. . | Fold change* . | Description . |
|---|---|---|
| Transcription factors | ||
| NM_001186 | −2.11 | Helicase, basic leucine zipper transcription factor-1 |
| NM_006963, AA744771 | 29.27 | Zinc finger protein 22 (KOX 15) |
| NM_006291 | 5.05 | Zinc finger protein 185 (LIM domain) |
| NM_014368 | 2.91 | LIM homeobox protein 6 |
| NM_001290 | −5.20 | LIM domain binding 2 |
| NM_002586 | −2.75 | Pre-B-cell leukemia transcription factor-2 (PBX-2) |
| X16155 | −2.79 | COUP-transcription factor |
| Signal transduction | ||
| NM_004445 | −2.38 | Erythropoietin-producing hepatocyte kinase (EphB6) |
| NM_002547 | 2.95 | Oligophrenin 1 |
| NM_002821 | 2.33 | Protein tyrosine kinase 7 |
| U71075 | −2.48 | Protein tyrosine phosphatase, receptor type, U |
| D30751 | 2.79 | Bone morphogenetic protein 4 |
| NM_022159 | −2.92 | EGF-TM-7-latrophilin-related protein |
| Cell growth, proliferation, and maintenance | ||
| NM_013975 | 2.04 | Ligase III, DNA |
| NM_006567 | 2.11 | Phenylalanine-tRNA synthetase |
| AU118882, NM_001957 | −2.90 | Endothelin receptor type A |
| NM_002349 | 14.32 | Lymphocyte antigen 75, gp200-MR6 |
| NM_005330 | −7.63 | Hemoglobin, epsilon 1, oxygen transport |
| NM_000385 | 2.30 | Aquaporin 1 |
| AF052169 | 2.48 | Voltage-gated potassium channel activity |
| BE742268 | −4.21 | Sortilin 1 (SORT 1) |
| AW206786 | −2.32 | Enigma (LIM domain protein) |
| Invasion and metastasis | ||
| M34064 | −2.13 | N-cadherin |
| NM_014751 | 2.06 | Metastasis suppressor gene |
| NM_002961 | 2.79 | S100 calcium-binding protein A4 |
| NM_021111 | 2.64 | Reversion-inducing cysteine-rich protein with kazal motif (RECK) |
| AF348491, AJ224869 | −4.21, −27.40 | Chemokine (C-X-C motif), receptor 4 (fusin) |
| NM_022842 | −18.70 | CUB domain-containing protein 1 (CDCP1) |
| Oncogenes/tumor suppressor genes | ||
| NM_021991 | −2.21 | Junction plakoglobin |
| NM_003287 | 2.10 | Tumor protein D52-like 1 |
| NM_001958 | 6.85 | Eukaryotic translation elongation factor 1 alpha 2 (EEF 1A2) |
| Apoptosis | ||
| NM_005892 | −2.14 | Formin-like (FRL) |
| NM_020371 | −2.11 | Cell death regulator Aven |
| Angiogenesis | ||
| NM_002019 | −2.24 | FLT, VEGFR1, Fms-related tyrosine kinase receptor |
| NM_000584 | −6.99 | Interleukin-8 (IL-8, C-X-CL8) |
| A1812030 | −3.39 | Thrombospondin 1 precursor |
| L01639 | −8.03 | Neuropeptide Y receptor |
| U58111 | −2.41 | Vascular endothelial growth factor C |
| NM_006291 | 2.98 | Tumor necrosis factor, alpha-induced protein 2 |
| Extracellular matrix | ||
| NM_002607 | 2.53 | Platelet-derived growth factor alpha polypeptide |
| NM_021599 | −4.62 | ADAM-TS2 |
| BC002416 | −2.29 | Biglycan |
| NM_000088 | 3.51 | Collagen, type I, alpha 1 |
| AI264196 | −2.48 | Fibrillin 1 precursor |
| D32039 | −2.13 | Chondroitin sulfate proteoglycan 2 (versican) |
| AI146848 | 2.87 | Dermatopontin precursor |
| AJ276395 | −3.80 | Fibronectin 1 |
| AA669336 | 7.26 | Alpha 1 chain of type XII collagen |
| Others | ||
| NM_002759 | 2.51 | EIF2Ak1, protein kinase, PKR |
| NM_004988 | −2.95 | Melanoma antigen family A1 (MAGE-A1) |
| NM_016931 | −2.46 | NADPH oxidase 4 (Nox 4) |
| NM_021822 | 2.80 | Phorbolin-like protein MDS019 |
| NM_001785 | 35.30 | Cytidine deaminase |
+ and − indicate increased and decreased mRNA levels, respectively; LIM, the Lin-1, IsI-1, and Mec-3 protein domain; COUP, chicken ovalbumin upstream promoter-transcription factors; TM7, transmembrane domain 7; gp200-MR6, a 200 000 Mr antigen detected by monoclonal antibody MR6; Fms, a protooncogene from the feline McDonough strain of sarcoma virus; ADAM-TS2, A disintegrin-like and metalloproteinase with thrombospondin type 1 motifs, 2; EIF2Ak1, eukaryotic translation initiation factor 2 α kinase 1; and PKR, double-stranded RNA-dependent protein kinase.
The number indicates the fold change in mRNA abundance in TFPI-2-expressing tumors over mock-transfected tumors determined by microarray data analysis.