Characteristics of 5 patients with PNH undergoing nonmyeloablative hematopoietic cell transplantation
Patient no. . | Age, y . | Sex . | Disease duration, mo* . | GPI-negative granulocytes, %† . | GPI-negative RBCs, %‡ . | Pretransplantation hemoglobin level, g/L . | Pretransplantation platelet count, × 109/L . | Indication for transplantation . |
|---|---|---|---|---|---|---|---|---|
| 1 | 30 | M | 15 | 92 | 64 | 92 | 43 | RBC transfusion dependent, portal vein thrombosis |
| 2 | 25 | F | 31 | 97 | 45 | 77 | 154 | RBC transfusion dependent, lower extremity DVT |
| 3 | 35 | M | 23 | 92 | 22 | 75 | 15 | RBC transfusion dependent, pancytopenia |
| 4§ | 26 | F | 15 | 13 | 1.1 | 84 | 28 | RBC and platelet transfusion dependent, pancytopenia |
| 5 | 35 | M | 49 | 92 | 36 | 82 | 36 | Splenic vein thrombosis, pancytopenia |
Patient no. . | Age, y . | Sex . | Disease duration, mo* . | GPI-negative granulocytes, %† . | GPI-negative RBCs, %‡ . | Pretransplantation hemoglobin level, g/L . | Pretransplantation platelet count, × 109/L . | Indication for transplantation . |
|---|---|---|---|---|---|---|---|---|
| 1 | 30 | M | 15 | 92 | 64 | 92 | 43 | RBC transfusion dependent, portal vein thrombosis |
| 2 | 25 | F | 31 | 97 | 45 | 77 | 154 | RBC transfusion dependent, lower extremity DVT |
| 3 | 35 | M | 23 | 92 | 22 | 75 | 15 | RBC transfusion dependent, pancytopenia |
| 4§ | 26 | F | 15 | 13 | 1.1 | 84 | 28 | RBC and platelet transfusion dependent, pancytopenia |
| 5 | 35 | M | 49 | 92 | 36 | 82 | 36 | Splenic vein thrombosis, pancytopenia |
DVT indicates deep vein thrombosis.
The duration from the diagnosis of PNH to transplantation.
The percentage of GPI-anchored protein-negative granulocytes prior to transplantation.
The percentage of GPI-anchored protein-negative red blood cells prior to transplantation.
Patient no. 4 had a diagnosis of aplastic anemia and PNH.