Table 2.

Bone marrow biopsy response to imatinib mesylate in patients with MHES

Cellularity
Reticulin staining*
Atypical mast cells†
Patient no.
Before
After
Before
After
Before
After
1   100   60   3   Focal   +   -  
2   40   30   0   0   +   -  
3   95   50   3   2   +   -  
4   100   50   4   1   +   -  
5   30   30   2   0   +   -  
7
 		 40
 		 30
 		 3
 		 2
 		 +
 		 -
 
Cellularity
Reticulin staining*
Atypical mast cells†
Patient no.
Before
After
Before
After
Before
After
1   100   60   3   Focal   +   -  
2   40   30   0   0   +   -  
3   95   50   3   2   +   -  
4   100   50   4   1   +   -  
5   30   30   2   0   +   -  
7
 		 40
 		 30
 		 3
 		 2
 		 +
 		 -
 
*

Reticulin staining was graded on a scale of 0-4 with 0 indicating no staining present.

†

Detected by antitryptase antibody staining; + indicates increased mast cell numbers, with spindle-shaped mast cells representing ≥ 25% of mast cells present in marrow; and -, normal mast cell numbers and morphology.

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