Nucleotide numbering according to Mancuso et al.²⁰  Amino acid positions that are not in parentheses are from the start methionine of pre—pro-VWF; amino acid positions in parentheses are from residue 1 of the mature VWF subunit. The numbering schemes can be respectively interconverted by the subtraction or addition of 763. With the exception of the silent C/T 24/1171 SNP revealed in the present study, all other polymorphisms are reported in the international VWF database (http://www.shef.ac.uk/vwf/polymorphisms/ex28.html).