Table 1. Clinical features of infant and... | American Society of Hematology

Table 1.

Clinical features of infant and pediatric ALL patients with FLT3-D835/I836 mutations

Patient	Age	Sex	WBCs × 10⁴/μL	DNA index	Relapse	Prognosis	FLT3-D835/I836 mutations
Infants
1^*	4 mo	M	67.6	ND	+	Dead	I836M
2^*	3 mo	M	14.6	ND	−	Alive	D835E
3†	3 mo	F	2.5	ND	+	Dead	D835Y
4†	6 mo	F	12.3	ND	+	Dead	D835Y
5†	6 mo	M	99.3	ND	+	Dead	D835H
6†	4 mo	M	53.7	ND	−	Dead	I836del
7^*	2 mo	F	95.3	ND	+	Dead	D835Y
8^*	2 mo	F	50.0	ND	−	Alive	I836del
Children
9	3 y	M	7.4	1.19‡	−	Alive	I836M
10	2 y	F	18.5	1.15‡	−	Alive	I836M
11	4 y	F	6.9	1.2‡	−	Alive	D835H
12	2 y	F	5.6	1.19§	−	Alive	I836M
13	3 y	M	5.8	0.99‡	−	Alive	D835E
14	7 y	M	102.7	1.0§	−	Alive	9-bp del + 6-bp ins∥

Patient	Age	Sex	WBCs × 10⁴/μL	DNA index	Relapse	Prognosis	FLT3-D835/I836 mutations
Infants
1^*	4 mo	M	67.6	ND	+	Dead	I836M
2^*	3 mo	M	14.6	ND	−	Alive	D835E
3†	3 mo	F	2.5	ND	+	Dead	D835Y
4†	6 mo	F	12.3	ND	+	Dead	D835Y
5†	6 mo	M	99.3	ND	+	Dead	D835H
6†	4 mo	M	53.7	ND	−	Dead	I836del
7^*	2 mo	F	95.3	ND	+	Dead	D835Y
8^*	2 mo	F	50.0	ND	−	Alive	I836del
Children
9	3 y	M	7.4	1.19‡	−	Alive	I836M
10	2 y	F	18.5	1.15‡	−	Alive	I836M
11	4 y	F	6.9	1.2‡	−	Alive	D835H
12	2 y	F	5.6	1.19§	−	Alive	I836M
13	3 y	M	5.8	0.99‡	−	Alive	D835E
14	7 y	M	102.7	1.0§	−	Alive	9-bp del + 6-bp ins∥

MLL rearrangements were found in all infants. WBCs refers to white blood cells.

t (4;11).

t (11;19).

Normal karyotype.

Not available.

Deletion (D835-S838) + insertion (A835, L836, G837).