Multivariate analyses of factors affecting TRM at day 90 and day 365
. | Relative risk estimate (95% CI) . | Step . | P . |
|---|---|---|---|
| Day 90 | |||
| More than 5 apoptotic cells within the infiltrate | 12.1 (4.1-35.7) | 1 | < .0001 |
| Acute GvHD of the liver, stage II or higher | 4.7 (1.8-12.3) | 2 | < .0001 |
| Day 365 | |||
| More than 5 apoptotic cells within the infiltrate | 14.8 (5.6-39.7) | 1 | < .0001 |
| Chronic GvHD | 8.0 (3.3-19.4) | 2 | < .0001 |
| Acute GvHD of the liver, stage II or higher | 4.1 (2.2-7.5) | 3 | < .0001 |
. | Relative risk estimate (95% CI) . | Step . | P . |
|---|---|---|---|
| Day 90 | |||
| More than 5 apoptotic cells within the infiltrate | 12.1 (4.1-35.7) | 1 | < .0001 |
| Acute GvHD of the liver, stage II or higher | 4.7 (1.8-12.3) | 2 | < .0001 |
| Day 365 | |||
| More than 5 apoptotic cells within the infiltrate | 14.8 (5.6-39.7) | 1 | < .0001 |
| Chronic GvHD | 8.0 (3.3-19.4) | 2 | < .0001 |
| Acute GvHD of the liver, stage II or higher | 4.1 (2.2-7.5) | 3 | < .0001 |
These models include both clinical parameters and elementary pathologic features. There was no statistical correlation between GvHD duration (and ensuing therapy with corticosteroids) with our findings of a worse prognosis for patients with the presence of more than 20 neutrophils per field or the presence of more than 5 apoptotic bodies per field within the cellular infiltrate. Indeed all but one patient with more than 20 neutrophils per field had biopsy within 3 days, as a mean, after the onset of GI symptoms. For patients who had more than 5 apoptotic bodies per field within the cellular infiltrate, all but one patient underwent biopsy within 3 days of the onset of digestive GvHD (multivariate analysis of TRM at day 90 and day 365).