Sensitivity and specificity of each pathologic feature in relation to clinical acute GvHD in 78 patients
. | 65 patients with acute GvHD, sensitivity estimate (95% CI) . | 13 patients without acute GvHD, specificity estimate, % . | P . |
|---|---|---|---|
| Pathologic GvHD | 85 (73-93) | 69 | < .0001 |
| Edema, moderate or more | 45 (32-58) | 100 | .0014 |
| Lymphocytes, more than 20/field | 69 (56-80) | 77 | .0018 |
| Presence of apoptotic epithelial cells* | 85 (73-93) | 69 | < .0001 |
| Presence of apoptotic cells in the infiltrate* | 57 (44-70) | 92 | .0015 |
| Fas expression in the cellular infiltrate† | 63 (50-75) | 77 | .0079 |
| TNF, more than 20 positive cells/field | 54 (41-67) | 92 | .0022 |
. | 65 patients with acute GvHD, sensitivity estimate (95% CI) . | 13 patients without acute GvHD, specificity estimate, % . | P . |
|---|---|---|---|
| Pathologic GvHD | 85 (73-93) | 69 | < .0001 |
| Edema, moderate or more | 45 (32-58) | 100 | .0014 |
| Lymphocytes, more than 20/field | 69 (56-80) | 77 | .0018 |
| Presence of apoptotic epithelial cells* | 85 (73-93) | 69 | < .0001 |
| Presence of apoptotic cells in the infiltrate* | 57 (44-70) | 92 | .0015 |
| Fas expression in the cellular infiltrate† | 63 (50-75) | 77 | .0079 |
| TNF, more than 20 positive cells/field | 54 (41-67) | 92 | .0022 |
Sensitivity and specificity of intestinal features to predict the occurrence of clinical acute GvHD among patients whose biopsies were performed due to clinical symptoms.
Apoptotic cells as assessed by TUNEL.
Due to our definition of significance (P < .0025), this factor is considered as nonsignificant.