Antileukemic activity of ST1926 and ATRA in NB4-bearing SCID mice
Treatment . | No. of animals . | Dosage (mg/kg) . | BWL, % max . | MST (range) . | MST . | ILS, % . |
|---|---|---|---|---|---|---|
| Vehicle, orally | 8 | 0 | 0 | (29-35) | 34 | — |
| ST1926, orally | 8 | 30 | 6 | (39-48) | 41* | 21 |
| ST1926, orally | 8 | 40 | 17 | (36-50) | 46* | 3 |
| ST1926, orally | 8 | 50 | 15 | (13-50) | 49† | 44 |
| ATRA, orally | 8 | 40 | 0 | (28-43) | 34.5 | — |
| Vehicle, interperitoneally | 8 | 0 | 0 | (30-39) | 35.5 | — |
| ST1926, interperitoneally | 8 | 50 | 9 | (21-63) | 55.5* | 56 |
| ATRA, interperitoneally | 8 | 40 | 0 | (50-86) | 55* | 55 |
| ATRA + ST1926, interperitoneally | 8 | 40 + 50 | 14 | (56-84) | 67*‡ | 89 |
Treatment . | No. of animals . | Dosage (mg/kg) . | BWL, % max . | MST (range) . | MST . | ILS, % . |
|---|---|---|---|---|---|---|
| Vehicle, orally | 8 | 0 | 0 | (29-35) | 34 | — |
| ST1926, orally | 8 | 30 | 6 | (39-48) | 41* | 21 |
| ST1926, orally | 8 | 40 | 17 | (36-50) | 46* | 3 |
| ST1926, orally | 8 | 50 | 15 | (13-50) | 49† | 44 |
| ATRA, orally | 8 | 40 | 0 | (28-43) | 34.5 | — |
| Vehicle, interperitoneally | 8 | 0 | 0 | (30-39) | 35.5 | — |
| ST1926, interperitoneally | 8 | 50 | 9 | (21-63) | 55.5* | 56 |
| ATRA, interperitoneally | 8 | 40 | 0 | (50-86) | 55* | 55 |
| ATRA + ST1926, interperitoneally | 8 | 40 + 50 | 14 | (56-84) | 67*‡ | 89 |
SCID mice were xenografted with NB4 cells intraperitoneally and treated as stated in “Materials and methods” with the indicated dosages of ATRA and/or ST1346 5 times per week for 3 weeks. The effect on body weight is expressed as BWL, % (maximum body weight loss during treatments), and is calculated as: 100 - (average BW dayx/average BW day1 × 100). In addition, ILS, % was evaluated (increase life span of treated mice vs untreated mice) calculated as: 100 - [(median survival time (MST) of treated mice/median survival time of untreated mice) × 100].
BWL indicates body weight loss; MST, median survival time; ILS, increased life span; —, not applicable.
P < .001 versus vehicle (Mann-Whitney).
P < .01 versus vehicle (Mann-Whitney).
P < .05 versus ATRA (Mann-Whitney).