Clinical characteristics of B-CLL patients
Patient . | Sex . | Binet stage . | Age, y . | Lymphocyte count, mm3 . | Time from diagnosis . | VH mutational status . | Cytogenetics . |
|---|---|---|---|---|---|---|---|
| 1 | M | A | 72 | 80 000 | — | — | — |
| 2 | M | A | 73 | 110 000 | — | — | — |
| 3 | F | A | 46 | 257 000 | 5 y | — | Trisomy 12 |
| 4 | M | B | 72 | 122 000 | 6 mo | Unmutated | Trisomy 12 |
| 5 | F | A | 53 | 117 000 | 10 y | Mutated | Deletion 13 |
| 6A | M | B | 50 | 159 000 | 12 y | Mutated | Normal |
| 6B | 52 | 170 000 | 14 y | ||||
| 7 | F | C | 80 | 110 000 | 1 y | — | — |
| 8A | M | C | 65 | 64 000 | 4 y | — | — |
| 8B | 66 | 66 000 | 5 y | ||||
| 9 | M | C | 56 | 640 000 | 3 y | — | — |
| 10A | F | A | 70 | 92 000 | 3 y | Unmutated | — |
| 10B | 71 | 116 000 | 4 y | ||||
| 11 | F | A | 70 | 102 000 | > 20 y | — | — |
| 12 | F | A | 54 | 59 000 | First time | — | — |
| 13A | M | A | 66 | 37 000 | 1 y | — | Normal |
| 13B | 67 | 40 000 | 2 y | ||||
| 13C | 67 | 45 000 | 2 y | ||||
| 14 | M | A | 78 | 142 000 | 10 y | — | Deletions 13 + 11 |
| 15A | M | B | 60 | 25 000 | 3 y | Unmutated | Deletion 11 |
| 15B | 60 | 43 000 | 3 y | ||||
| 15C | 61 | 97 000 | 4 y | ||||
| 16 | F | A | 67 | 17 000 | 4 y | Mutated | — |
| 17 | F | B | 60 | 67 000 | 3 y | Mutated | — |
| 18A | F | A | 63 | 162 000 | 2 y | Mutated | Normal |
| 18B | 64 | 165 000 | 2 y | ||||
| 18C | 64 | 140 000 | 2 y | ||||
| 19 | F | A | 75 | 105 000 | — | — | — |
| 20 | M | B | 58 | 80 000 | 3 y | Mutated | Deletion 13 |
| 21 | M | A | 70 | 72 000 | 2 y | — | — |
| 22 | M | A | 51 | 19 000 | First time | — | — |
| 23 | M | A | 75 | 20 000 | 1 y | — | — |
Patient . | Sex . | Binet stage . | Age, y . | Lymphocyte count, mm3 . | Time from diagnosis . | VH mutational status . | Cytogenetics . |
|---|---|---|---|---|---|---|---|
| 1 | M | A | 72 | 80 000 | — | — | — |
| 2 | M | A | 73 | 110 000 | — | — | — |
| 3 | F | A | 46 | 257 000 | 5 y | — | Trisomy 12 |
| 4 | M | B | 72 | 122 000 | 6 mo | Unmutated | Trisomy 12 |
| 5 | F | A | 53 | 117 000 | 10 y | Mutated | Deletion 13 |
| 6A | M | B | 50 | 159 000 | 12 y | Mutated | Normal |
| 6B | 52 | 170 000 | 14 y | ||||
| 7 | F | C | 80 | 110 000 | 1 y | — | — |
| 8A | M | C | 65 | 64 000 | 4 y | — | — |
| 8B | 66 | 66 000 | 5 y | ||||
| 9 | M | C | 56 | 640 000 | 3 y | — | — |
| 10A | F | A | 70 | 92 000 | 3 y | Unmutated | — |
| 10B | 71 | 116 000 | 4 y | ||||
| 11 | F | A | 70 | 102 000 | > 20 y | — | — |
| 12 | F | A | 54 | 59 000 | First time | — | — |
| 13A | M | A | 66 | 37 000 | 1 y | — | Normal |
| 13B | 67 | 40 000 | 2 y | ||||
| 13C | 67 | 45 000 | 2 y | ||||
| 14 | M | A | 78 | 142 000 | 10 y | — | Deletions 13 + 11 |
| 15A | M | B | 60 | 25 000 | 3 y | Unmutated | Deletion 11 |
| 15B | 60 | 43 000 | 3 y | ||||
| 15C | 61 | 97 000 | 4 y | ||||
| 16 | F | A | 67 | 17 000 | 4 y | Mutated | — |
| 17 | F | B | 60 | 67 000 | 3 y | Mutated | — |
| 18A | F | A | 63 | 162 000 | 2 y | Mutated | Normal |
| 18B | 64 | 165 000 | 2 y | ||||
| 18C | 64 | 140 000 | 2 y | ||||
| 19 | F | A | 75 | 105 000 | — | — | — |
| 20 | M | B | 58 | 80 000 | 3 y | Mutated | Deletion 13 |
| 21 | M | A | 70 | 72 000 | 2 y | — | — |
| 22 | M | A | 51 | 19 000 | First time | — | — |
| 23 | M | A | 75 | 20 000 | 1 y | — | — |
VH status was defined as mutated if DNA sequences from leukemic cells differed 2% or more from germline. For some patients, blood samples were collected at different times as indicated by the letters. — indicates not tested.