MMTHFR genotypes in ALL patients and their mothers
MTHFR genotypes . | . | . | . | . | . | . | . | . | |
|---|---|---|---|---|---|---|---|---|---|
| C677T . | A1298C . | ALL, no. (%) . | Mothers, no. (%) . | Controls, no. (%) . | ORALL (95% CI) . | PALL . | ORmothers (95% CI) . | Pmothers . | |
| CC | AA | 18 (18.9) | 14 (14.9) | 35 (11.7) | 1 (referent) | — | 1 (referent) | — | |
| CT | AA | 25 (26.3) | 27 (28.7) | 69 (23.0) | 0.7 (0.3-1.5) | .4 | 1.0 (0.5-2.1) | NS | |
| TT | AA | 13 (13.7) | 17 (18.1) | 46 (15.3) | 0.5 (0.2-1.3) | .2 | 0.7 (0.3-1.6) | .5 | |
| CC | AC | 15 (15.8) | 19 (20.2) | 60 (20.0) | 0.5 (0.2-1.1) | .1 | 0.7 (0.3-1.5) | .4 | |
| CT | AC | 21 (22.1) | 12 (12.8) | 59 (19.7) | 0.7 (0.3-1.5) | .4 | 1.4 (0.6-3.7) | .5 | |
| CC | CC | 3 (3.2) | 5 (5.3) | 31 (10.3) | 0.2 (0.05-0.7) | < .01 | 0.4 (0.1-1.2) | .1 | |
MTHFR genotypes . | . | . | . | . | . | . | . | . | |
|---|---|---|---|---|---|---|---|---|---|
| C677T . | A1298C . | ALL, no. (%) . | Mothers, no. (%) . | Controls, no. (%) . | ORALL (95% CI) . | PALL . | ORmothers (95% CI) . | Pmothers . | |
| CC | AA | 18 (18.9) | 14 (14.9) | 35 (11.7) | 1 (referent) | — | 1 (referent) | — | |
| CT | AA | 25 (26.3) | 27 (28.7) | 69 (23.0) | 0.7 (0.3-1.5) | .4 | 1.0 (0.5-2.1) | NS | |
| TT | AA | 13 (13.7) | 17 (18.1) | 46 (15.3) | 0.5 (0.2-1.3) | .2 | 0.7 (0.3-1.6) | .5 | |
| CC | AC | 15 (15.8) | 19 (20.2) | 60 (20.0) | 0.5 (0.2-1.1) | .1 | 0.7 (0.3-1.5) | .4 | |
| CT | AC | 21 (22.1) | 12 (12.8) | 59 (19.7) | 0.7 (0.3-1.5) | .4 | 1.4 (0.6-3.7) | .5 | |
| CC | CC | 3 (3.2) | 5 (5.3) | 31 (10.3) | 0.2 (0.05-0.7) | < .01 | 0.4 (0.1-1.2) | .1 | |
The frequency of MTHFR genotypes in ALL patients (n = 95) and their mothers (n = 94) was compared with the frequency in controls. The referent group (OR = 1) comprised controls and either patients or mothers homozygous for C677A1298 haplotype.
— indicates not applicable; NS, not significant.