MTHFR genotypes in ALL patients stratified by the year of birth
MTHFR genotypes . | . | . | . | . | . | . | . | . | |
|---|---|---|---|---|---|---|---|---|---|
| C677T . | A1298C . | Born before January 1996, no. (%) . | Born after January 1996, no. (%) . | Controls, no. (%) . | ORbefore 1996 (95% CI) . | Pbefore 1996 . | ORafter 1996 (95% CI) . | Pafter 1996 . | |
| CC | AA | 48 (21.6) | 3 (6.3) | 35 (11.7) | 1 (referent) | — | 1 (referent) | — | |
| CT | AA | 51 (23.0) | 18 (37.5) | 69 (23.0) | 0.5 (0.3-0.9) | .03 | 3.0 (0.8-11) | .1 | |
| TT | AA | 26 (11.7) | 5 (10.4) | 46 (15.3) | 0.4 (0.2-0.8) | .01 | 1.3 (0.3-5.7) | NS | |
| CC | AC | 36 (16.2) | 13 (27.1) | 60 (20.0) | 0.4 (0.2-0.8) | < .01 | 2.5 (0.7-9.5) | .3 | |
| CT | AC | 49 (22.1) | 9 (18.8) | 59 (19.7) | 0.6 (0.3-1.1) | .1 | 1.8 (0.5-7.0) | .5 | |
| CC | CC | 12 (5.4) | 0 (0) | 31 (10.3) | 0.3 (0.1-0.6) | < .01 | ND | .3 | |
MTHFR genotypes . | . | . | . | . | . | . | . | . | |
|---|---|---|---|---|---|---|---|---|---|
| C677T . | A1298C . | Born before January 1996, no. (%) . | Born after January 1996, no. (%) . | Controls, no. (%) . | ORbefore 1996 (95% CI) . | Pbefore 1996 . | ORafter 1996 (95% CI) . | Pafter 1996 . | |
| CC | AA | 48 (21.6) | 3 (6.3) | 35 (11.7) | 1 (referent) | — | 1 (referent) | — | |
| CT | AA | 51 (23.0) | 18 (37.5) | 69 (23.0) | 0.5 (0.3-0.9) | .03 | 3.0 (0.8-11) | .1 | |
| TT | AA | 26 (11.7) | 5 (10.4) | 46 (15.3) | 0.4 (0.2-0.8) | .01 | 1.3 (0.3-5.7) | NS | |
| CC | AC | 36 (16.2) | 13 (27.1) | 60 (20.0) | 0.4 (0.2-0.8) | < .01 | 2.5 (0.7-9.5) | .3 | |
| CT | AC | 49 (22.1) | 9 (18.8) | 59 (19.7) | 0.6 (0.3-1.1) | .1 | 1.8 (0.5-7.0) | .5 | |
| CC | CC | 12 (5.4) | 0 (0) | 31 (10.3) | 0.3 (0.1-0.6) | < .01 | ND | .3 | |
The frequency of MTHFR genotype combinations of each group of ALL patients, born before (n = 222) and after January 1996 (n = 48), was compared with the frequency in controls using CC677/AA1298 individuals as the referent group (OR = 1). When CC677/AA1298 individuals are compared with others, the ALL risk (OR) in the group born before 1996 was 2.2 (95% CI, 1.3-3.5; P = .001) and for those born after 1996, OR = 0.5 (95% CI, 0.1-1.8; P = .4).
ND indicates not determined due to zero observations; NS, not significant; and —, not applicable.