Analysis of MTHFR genotypes in children with ALL and controls
MTHFR genotypes . | . | . | . | . | . | |
|---|---|---|---|---|---|---|
| C677T . | A1298C . | ALL patients, no. (%) . | Controls, no. (%) . | OR (95% CI) . | P . | |
| CC | AA | 51 (18.9) | 35 (11.7) | 1.0 (referent) | — | |
| CT | AA | 69 (25.6) | 69 (23.0) | 0.7 (0.4-1.2) | .2 | |
| TT | AA | 31 (11.5) | 46 (15.3) | 0.4 (0.2-0.9) | .02 | |
| CC | AC | 49 (18.1) | 60 (20.0) | 0.6 (0.3-1.0) | .06 | |
| CT | AC | 58 (21.5) | 59 (19.7) | 0.7 (0.4-1.2) | .2 | |
| CC | CC | 12 (4.4) | 31 (10.3) | 0.3 (0.1-0.6) | < .001 | |
MTHFR genotypes . | . | . | . | . | . | |
|---|---|---|---|---|---|---|
| C677T . | A1298C . | ALL patients, no. (%) . | Controls, no. (%) . | OR (95% CI) . | P . | |
| CC | AA | 51 (18.9) | 35 (11.7) | 1.0 (referent) | — | |
| CT | AA | 69 (25.6) | 69 (23.0) | 0.7 (0.4-1.2) | .2 | |
| TT | AA | 31 (11.5) | 46 (15.3) | 0.4 (0.2-0.9) | .02 | |
| CC | AC | 49 (18.1) | 60 (20.0) | 0.6 (0.3-1.0) | .06 | |
| CT | AC | 58 (21.5) | 59 (19.7) | 0.7 (0.4-1.2) | .2 | |
| CC | CC | 12 (4.4) | 31 (10.3) | 0.3 (0.1-0.6) | < .001 | |
The risk of ALL for the CC677/AA1298 individuals compared with all other genotypes is 1.8 (95% CI, 1.1-2.8; P = .02). No individual with the following genotypes was observed: TT677/AC1298, TT677/CC1298, and CT677/CC1298.
OR indicates crude odds ratio; CI, confidence interval; and —, not applicable.