Causes of acquired thrombocytopenia
Immune causes |
| Immune thrombocytopenic purpura (ITP) |
| Neonatal alloimmune thrombocytopenia |
| Posttransfusion purpura (PTP) |
| Nonimmune causes |
| Shortened circulation |
| Disseminated intravascular coagulopathy (DIC) |
| Thrombotic thromobcytopenic purpura (TTP) |
| Heparin-induced thrombocytopenia (HIT) |
| Splenomegaly/splenic sequestration |
| Turbulent blood flow (hemangiomas, abnormal cardiac valves, intra-aortic balloon pumps) |
| Decreased production |
| Drug-induced marrow suppression |
| Chemotherapy |
| Viral infection (hepatitis C virus, HIV, cytomegalovirus) |
| Bacterial infection (sepsis) |
| Alcoholism/bone marrow suppression |
| Myelodysplastic syndrome (MDS) |
| Myelofibrosis/myelophthisis |
| Aplastic anemia |
| Hematologic malignancy (leukemias, lymphomas, myeloma) |
| Solid tumor infiltrating bone marrow |
Immune causes |
| Immune thrombocytopenic purpura (ITP) |
| Neonatal alloimmune thrombocytopenia |
| Posttransfusion purpura (PTP) |
| Nonimmune causes |
| Shortened circulation |
| Disseminated intravascular coagulopathy (DIC) |
| Thrombotic thromobcytopenic purpura (TTP) |
| Heparin-induced thrombocytopenia (HIT) |
| Splenomegaly/splenic sequestration |
| Turbulent blood flow (hemangiomas, abnormal cardiac valves, intra-aortic balloon pumps) |
| Decreased production |
| Drug-induced marrow suppression |
| Chemotherapy |
| Viral infection (hepatitis C virus, HIV, cytomegalovirus) |
| Bacterial infection (sepsis) |
| Alcoholism/bone marrow suppression |
| Myelodysplastic syndrome (MDS) |
| Myelofibrosis/myelophthisis |
| Aplastic anemia |
| Hematologic malignancy (leukemias, lymphomas, myeloma) |
| Solid tumor infiltrating bone marrow |