Clinical and cellular features of ATM-mutant B-CLL tumors analyzed in microarray experiments
Tumor . | ATM mutation . | p53 induction . | VH status . | Clinical course . |
|---|---|---|---|---|
| ATM1 | 8600G > A (2867G > E) and LOH across ATM | D | Unmutated | P |
| ATM2 | 1058delGT and 5464G > A (1822E > Q) | D | Unmutated | P |
| ATM3 | 8266A > T (2756K > stop) | D | Unmutated | P |
| ATM4 | 2144insA and 4393insA | D | Unmutated | P |
| ATM5 | 8084G > C (2695G > A) and 7351G > A (2451A > T) | D | Unmutated | P |
| ATM6 | 8839A > C (2947T > S) and LOH across ATM | D | Unmutated | P |
Tumor . | ATM mutation . | p53 induction . | VH status . | Clinical course . |
|---|---|---|---|---|
| ATM1 | 8600G > A (2867G > E) and LOH across ATM | D | Unmutated | P |
| ATM2 | 1058delGT and 5464G > A (1822E > Q) | D | Unmutated | P |
| ATM3 | 8266A > T (2756K > stop) | D | Unmutated | P |
| ATM4 | 2144insA and 4393insA | D | Unmutated | P |
| ATM5 | 8084G > C (2695G > A) and 7351G > A (2451A > T) | D | Unmutated | P |
| ATM6 | 8839A > C (2947T > S) and LOH across ATM | D | Unmutated | P |
D indicates defective; P, progressive.