Molecular profiles in Hodgkin disease
Molecule . | Classical Hodgkin disease (Reed-Sternberg cells) . | LPHD (L&H cells) . |
|---|---|---|
| Immunohistologic labeling* | ||
| Published data | ||
| Ig, J chain | Neg | Pos |
| CD20, CD79 | Usually neg | Pos |
| CD15, CD30, CD138 | Pos | Neg |
| CD45 | Neg | Pos |
| BCL-6 | Neg/pos | Pos |
| EMA | Neg | Pos |
| OCT-1 | Pos/neg | Pos |
| OCT-2, BOB.1 | Neg/pos | Pos |
| PU.1 | Neg | Pos |
| PAX-5 (BSAP) | Pos | Pos |
| MUM-1 | Pos | Neg |
| Present study | ||
| Lyn | Neg (with rare exceptions) | Usually neg |
| Fyn | Pos/neg | Pos |
| Syk | Neg | Pos |
| BLNK | Neg | Pos |
| PLC-γ2 | Neg | Pos |
| Gene expression profiling† | ||
| Ig-(kappa) | Down-regulated | No data |
| CD20 | Down-regulated | No data |
| CD79 | Down-regulated | No data |
| CD45 | Down-regulated | No data |
| Lyn | Down-regulated | No data |
| Syk | Down-regulated | No data |
| BLNK | Down-regulated | No data |
| PLC-γ2 | Down-regulated | No data |
Molecule . | Classical Hodgkin disease (Reed-Sternberg cells) . | LPHD (L&H cells) . |
|---|---|---|
| Immunohistologic labeling* | ||
| Published data | ||
| Ig, J chain | Neg | Pos |
| CD20, CD79 | Usually neg | Pos |
| CD15, CD30, CD138 | Pos | Neg |
| CD45 | Neg | Pos |
| BCL-6 | Neg/pos | Pos |
| EMA | Neg | Pos |
| OCT-1 | Pos/neg | Pos |
| OCT-2, BOB.1 | Neg/pos | Pos |
| PU.1 | Neg | Pos |
| PAX-5 (BSAP) | Pos | Pos |
| MUM-1 | Pos | Neg |
| Present study | ||
| Lyn | Neg (with rare exceptions) | Usually neg |
| Fyn | Pos/neg | Pos |
| Syk | Neg | Pos |
| BLNK | Neg | Pos |
| PLC-γ2 | Neg | Pos |
| Gene expression profiling† | ||
| Ig-(kappa) | Down-regulated | No data |
| CD20 | Down-regulated | No data |
| CD79 | Down-regulated | No data |
| CD45 | Down-regulated | No data |
| Lyn | Down-regulated | No data |
| Syk | Down-regulated | No data |
| BLNK | Down-regulated | No data |
| PLC-γ2 | Down-regulated | No data |
Neg indicates negative; Pos, positive; Neg/pos, majority of cells negative; Pos/neg, majority of cells positive.
The data on Hodgkin disease cases comprise immunohistologic results from the literature.
The data on gene expression profiling come from Schwering et al,3 and we have included results only for genes relevant to the immunohistologic labeling studies.