Summary of protease involvement in GROβT-, G-CSF-, and synergistic combination-induced PBSC mobilization in the mouse
. | GROβ/GROβT . | G-CSF . | G-CSF + GROβ/GROβT . |
|---|---|---|---|
| Marrow EVC | |||
| MMP-9 | ++ | ++ | + (↓) |
| NE | ↔ | ++ | + (↓) |
| CG | ↔ | ++ | + (↓) |
| SDF-1 | ↔ | ↓ ↓ | ↓ (↑) |
| PMN | ↔ | + | ↓ |
| Blood plasma | |||
| MMP-9 | ++ | ++ | ++++ |
| NE | ↔ | ↔ | ↔ |
| CG | ↔ | ↔ | ↔ |
| SDF-1 | ↔ | ↓ | ↓ |
| PMN | ↔ | + | ++ |
. | GROβ/GROβT . | G-CSF . | G-CSF + GROβ/GROβT . |
|---|---|---|---|
| Marrow EVC | |||
| MMP-9 | ++ | ++ | + (↓) |
| NE | ↔ | ++ | + (↓) |
| CG | ↔ | ++ | + (↓) |
| SDF-1 | ↔ | ↓ ↓ | ↓ (↑) |
| PMN | ↔ | + | ↓ |
| Blood plasma | |||
| MMP-9 | ++ | ++ | ++++ |
| NE | ↔ | ↔ | ↔ |
| CG | ↔ | ↔ | ↔ |
| SDF-1 | ↔ | ↓ | ↓ |
| PMN | ↔ | + | ++ |
↔ indicates no significant change; ++, significant increase < 20-fold; ++++, significant increase > 20 fold; ↓ and ↓ ↓, significant decrease; (↓)/(↑), net effective decrease/increase compared to either compound used.
EVC indicates extravascular compartment.