Table 2. Inverse correlation between... | American Society of Hematology

Table 2.

Inverse correlation between cellular drug resistance and the activation of parameters along the effector route of apoptosis in pediatric ALL

Apoptotic parameter	LC₅₀ prednisolone	LC₅₀ vincristine	LC₅₀l-asparaginase	LC₅₀ daunorubicin
PS externalization
Correlation coefficient	−.59	−.52	−.72	−.46
P	<.001	.002	<.001	.008
N	32	33	32	32
ΔΨ_m depolarization
Correlation coefficient	−.43	−.45	−.45	−.54
P	.016	.014	.010	.002
N	31	30	32	29
Caspase-3 activation
Correlation coefficient	−.60	−.28	−.46	−.27
P	.001	.118	.011	.146
N	29	32	30	31
PARP inactivation
Correlation coefficient	−.58	−.34	−.58	−.27
P	.001	.059	.001	.160
N	29	32	29	29

Apoptotic parameter	LC₅₀ prednisolone	LC₅₀ vincristine	LC₅₀l-asparaginase	LC₅₀ daunorubicin
PS externalization
Correlation coefficient	−.59	−.52	−.72	−.46
P	<.001	.002	<.001	.008
N	32	33	32	32
ΔΨ_m depolarization
Correlation coefficient	−.43	−.45	−.45	−.54
P	.016	.014	.010	.002
N	31	30	32	29
Caspase-3 activation
Correlation coefficient	−.60	−.28	−.46	−.27
P	.001	.118	.011	.146
N	29	32	30	31
PARP inactivation
Correlation coefficient	−.58	−.34	−.58	−.27
P	.001	.059	.001	.160
N	29	32	29	29

See legend of Table 1.