Table 1. Correlation between PS... | American Society of Hematology

Table 1.

Correlation between PS externalization and the downstream apoptotic parameters upon drug exposure in pediatric ALL

Drug	Δψ_m depolarization	Caspase-3 activation	PARP inactivation
Prednisolone
Correlation coefficient	.81	.76	.76
P	<.001	<.001	<.001
N	31	29	29
Vincristine
Correlation coefficient	.80	.56	.64
P	<.001	<.001	<.001
N	30	32	32
l-asparaginase
Correlation coefficient	.42	.49	.56
P	.017	.006	.002
N	32	30	29
Daunorubicin
Correlation coefficient	.63	.50	.41
P	<.001	.005	.029
N	29	31	29

Drug	Δψ_m depolarization	Caspase-3 activation	PARP inactivation
Prednisolone
Correlation coefficient	.81	.76	.76
P	<.001	<.001	<.001
N	31	29	29
Vincristine
Correlation coefficient	.80	.56	.64
P	<.001	<.001	<.001
N	30	32	32
l-asparaginase
Correlation coefficient	.42	.49	.56
P	.017	.006	.002
N	32	30	29
Daunorubicin
Correlation coefficient	.63	.50	.41
P	<.001	.005	.029
N	29	31	29

Freshly isolated ALL cells were cultured for 18 hours in the presence of 50 μg/mL vincristine or 2.0 μg/mL daunorubicin or 42 hours in the presence of 250 μg/mL prednisolone or 10 IU/mL l-asparaginase. Drug-induced activation of apoptotic parameters was determined by flow cytometry. Correlation between apoptotic parameters was calculated using the Spearman rank correlation test.

View Large

This Feature Is Available To Subscribers Only