Multivariate analysis of predictors of etoposide clearance at week 54
. | Genotype . | No. . | Coefficient . | P . |
|---|---|---|---|---|
| Effects that do not interact with race | ||||
| Age, y | 40 | -0.013 | .041 | |
| Effects that interact with race | ||||
| VDR Fok 1 | ||||
| Black | CC | 7 | Baseline | .052 |
| CT | 5 | -0.11 | ||
| TT | 1 | -0.37 | ||
| White | CC | 12 | Baseline | .640 |
| CT | 12 | -0.02 | ||
| TT | 3 | -0.05 | ||
| UGT1A1 (TA) | ||||
| Black | 7/7 | 2 | Baseline | .039 |
| 6/7 | 8 | 0.30 | ||
| 6/6 | 3 | 0.46 | ||
| White | 7/7 | 2 | Baseline | .926 |
| 6/7 | 10 | 0.02 | ||
| 6/6 | 15 | 0.01 | ||
| VDR intron 8 | ||||
| Black | AA | 0 | .036 | |
| AG | 5 | Baseline | ||
| GG | 8 | 0.25 | ||
| White | AA | 4 | Baseline | .533 |
| AG | 10 | 0.03 | ||
| GG | 13 | 0.06 |
. | Genotype . | No. . | Coefficient . | P . |
|---|---|---|---|---|
| Effects that do not interact with race | ||||
| Age, y | 40 | -0.013 | .041 | |
| Effects that interact with race | ||||
| VDR Fok 1 | ||||
| Black | CC | 7 | Baseline | .052 |
| CT | 5 | -0.11 | ||
| TT | 1 | -0.37 | ||
| White | CC | 12 | Baseline | .640 |
| CT | 12 | -0.02 | ||
| TT | 3 | -0.05 | ||
| UGT1A1 (TA) | ||||
| Black | 7/7 | 2 | Baseline | .039 |
| 6/7 | 8 | 0.30 | ||
| 6/6 | 3 | 0.46 | ||
| White | 7/7 | 2 | Baseline | .926 |
| 6/7 | 10 | 0.02 | ||
| 6/6 | 15 | 0.01 | ||
| VDR intron 8 | ||||
| Black | AA | 0 | .036 | |
| AG | 5 | Baseline | ||
| GG | 8 | 0.25 | ||
| White | AA | 4 | Baseline | .533 |
| AG | 10 | 0.03 | ||
| GG | 13 | 0.06 |
For the overall multivariate model, r2 = 0.55, P < .001.
*Etoposide clearance was log transformed. Clearance is lower with a negative coefficient value or higher with a positive coefficient value. All estimates and P values were obtained by fitting a single model on all patients (n = 40). P values for terms interacting with race were obtained by F test using race-specific contrasts, after adjusting for other predictors in the model.