Multivariate analysis of genotypic predictors of etoposide clearance at day 29
. | Genotype . | No. . | Coefficient . | P . |
|---|---|---|---|---|
| Effects that do not interact with race | ||||
| MDR1 exon 26 | CC | 35 | Baseline | .002 |
| CT | 41 | -0.10 | ||
| TT | 26 | -0.19 | ||
| Effects that interact with race | ||||
| Age, y | ||||
| Black | 25 | -0.015 | .100 | |
| White | 77 | 0.005 | .275 | |
| CYP3A5 | ||||
| Black | AA | 12 | Baseline | .022 |
| AG | 11 | 0.12 | ||
| GG | 2 | 0.42 | ||
| White | AA | 1 | Baseline | .862 |
| AG | 20 | -0.14 | ||
| GG | 56 | -0.13 | ||
| GSTP1 | ||||
| Black | AA | 6 | Baseline | .034 |
| AG | 11 | 0.07 | ||
| GG | 8 | 0.22 | ||
| White | AA | 29 | Baseline | .198 |
| AG | 34 | -0.06 | ||
| GG | 14 | -0.07 |
. | Genotype . | No. . | Coefficient . | P . |
|---|---|---|---|---|
| Effects that do not interact with race | ||||
| MDR1 exon 26 | CC | 35 | Baseline | .002 |
| CT | 41 | -0.10 | ||
| TT | 26 | -0.19 | ||
| Effects that interact with race | ||||
| Age, y | ||||
| Black | 25 | -0.015 | .100 | |
| White | 77 | 0.005 | .275 | |
| CYP3A5 | ||||
| Black | AA | 12 | Baseline | .022 |
| AG | 11 | 0.12 | ||
| GG | 2 | 0.42 | ||
| White | AA | 1 | Baseline | .862 |
| AG | 20 | -0.14 | ||
| GG | 56 | -0.13 | ||
| GSTP1 | ||||
| Black | AA | 6 | Baseline | .034 |
| AG | 11 | 0.07 | ||
| GG | 8 | 0.22 | ||
| White | AA | 29 | Baseline | .198 |
| AG | 34 | -0.06 | ||
| GG | 14 | -0.07 |
For the overall multivariate model, r2 = 0.26, P < .001.
*Etoposide clearance was log-transformed. The clearance is lower with a negative coefficient value or higher with a positive coefficient value. All estimates and P values were obtained by fitting a single model on all patients (n = 102). P values for terms interacting with race were obtained by F test using race-specific contrasts, after adjusting for other predictors in the model.