Examples of genes down-regulated in EphB4-/- EBs by DNA array analysis
Gene name . | Annotation . |
|---|---|
| Developmental genes | |
| BMP-4 | Bone morphogenetic protein 4, mesodem induction |
| BMP-7 | BMP signaling |
| BMP-5 | BMP signaling |
| BMP-2 | BMP signaling |
| TGF-β1 | Transforming growth factor-β 1 |
| TGF-β2 | TGF-β signaling |
| TGF-βRI | TGF-β-type I receptor |
| TGF-βRII | TGF-β-type II receptor |
| Smad6 | Signal mediators of BMP and TGF-β signaling |
| LMP-1 | Lim protein-1, mediator of BMP-6 signaling |
| T-box 2 | T-box transcription factor, mesoderm development |
| IGF-2 | Insulin-like growth factor 2, mesoderm induction |
| IGFBP4 | Insulin-like growth factor binding protein 4 |
| FGF-3 | Early embryonic development, mesodermal marker |
| FGFR2 | FGF receptor 2 |
| Wnt5a | Frizzled ligand, Wnt signaling |
| wnt11 | Frizzled ligand, Wnt signaling |
| Pax3 | Paired-box transcription factor, myogenesis induction |
| Pax9 | Paired-box transcription factor |
| Endothelial lineage | |
| VEGF | Vascular endothelial growth factor, vasculogenesis |
| Tie2/Tek | Tyrosine kinase receptor, marker of endothelial cells |
| Hematopoietic lineage | |
| c-kit | Tyrosine kinase receptor of SCF |
| SCF | c-kit ligand (stem cell factor) |
| GATA-3 | Transcription factor, T-cell development |
| GATA-2 | Transcription factor, hematopoiesis |
| Scl/TAL-1 | Transcription factor, hematopoiesis |
| Runx1/AML1 | Transcription factor, hematopoiesis |
| CXCR4 | Chemokine receptor of SDF-1 |
| STAT5B | Transcription factor, hematopoiesis |
| GM-CSF-R | GM-CSF receptor |
| Myogenic lineage | |
| Myf6 | Myogenic transcription factor |
| Mylc2a | Myosin light chain regulatory A |
| Myla | Myosin light chain for cardiac atria |
| Mylf | Myosin light chain for fast skeletal muscle |
Gene name . | Annotation . |
|---|---|
| Developmental genes | |
| BMP-4 | Bone morphogenetic protein 4, mesodem induction |
| BMP-7 | BMP signaling |
| BMP-5 | BMP signaling |
| BMP-2 | BMP signaling |
| TGF-β1 | Transforming growth factor-β 1 |
| TGF-β2 | TGF-β signaling |
| TGF-βRI | TGF-β-type I receptor |
| TGF-βRII | TGF-β-type II receptor |
| Smad6 | Signal mediators of BMP and TGF-β signaling |
| LMP-1 | Lim protein-1, mediator of BMP-6 signaling |
| T-box 2 | T-box transcription factor, mesoderm development |
| IGF-2 | Insulin-like growth factor 2, mesoderm induction |
| IGFBP4 | Insulin-like growth factor binding protein 4 |
| FGF-3 | Early embryonic development, mesodermal marker |
| FGFR2 | FGF receptor 2 |
| Wnt5a | Frizzled ligand, Wnt signaling |
| wnt11 | Frizzled ligand, Wnt signaling |
| Pax3 | Paired-box transcription factor, myogenesis induction |
| Pax9 | Paired-box transcription factor |
| Endothelial lineage | |
| VEGF | Vascular endothelial growth factor, vasculogenesis |
| Tie2/Tek | Tyrosine kinase receptor, marker of endothelial cells |
| Hematopoietic lineage | |
| c-kit | Tyrosine kinase receptor of SCF |
| SCF | c-kit ligand (stem cell factor) |
| GATA-3 | Transcription factor, T-cell development |
| GATA-2 | Transcription factor, hematopoiesis |
| Scl/TAL-1 | Transcription factor, hematopoiesis |
| Runx1/AML1 | Transcription factor, hematopoiesis |
| CXCR4 | Chemokine receptor of SDF-1 |
| STAT5B | Transcription factor, hematopoiesis |
| GM-CSF-R | GM-CSF receptor |
| Myogenic lineage | |
| Myf6 | Myogenic transcription factor |
| Mylc2a | Myosin light chain regulatory A |
| Myla | Myosin light chain for cardiac atria |
| Mylf | Myosin light chain for fast skeletal muscle |
SDF-1 indicates stromal-derived factor 1; TGF-β, transforming growth factor β.