Expression of FLT3 and FL in leukemia/lymphoma-derived cell lines
. | FLT3 . | . | . | . | . | FL . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cell line . | Normal FLT3 mRNA . | ITD . | D835 . | FLT3 protein . | P-FLT3 . | FL mRNA . | MFI of FL by FACS . | |||||
| HL-60 | + | - | - | - | - | + | 12.0 | |||||
| ML-1 | + | - | - | + | - | + | 46.2 | |||||
| MOLM-1 | + | - | - | +++ | + | + | 40.8 | |||||
| K562 | - | - | - | - | - | + | 53.1 | |||||
| KG1a | + | - | - | + | - | + | 19.4 | |||||
| EM2 | + | - | - | - | - | + | 24.1 | |||||
| HEL | ± | - | - | - | - | + | 31.3 | |||||
| WSU-NHL | + | - | - | + | - | + | 68.2 | |||||
| U937 | + | - | - | - | - | + | 43.8 | |||||
| EM3 | + | - | - | ++ | - | + | 17.7 | |||||
| EOL-1 | + | - | - | ++++ | + | + | 37.6 | |||||
| LAZ221 | + | - | - | - | - | + | 14.1 | |||||
| MV4-11 | - | + | - | ++ | + | + | 13.1 | |||||
| REH | + | - | - | ++++ | + | + | 36.7 | |||||
| BV173 | + | - | - | ++++ | + | + | 25.2 | |||||
. | FLT3 . | . | . | . | . | FL . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cell line . | Normal FLT3 mRNA . | ITD . | D835 . | FLT3 protein . | P-FLT3 . | FL mRNA . | MFI of FL by FACS . | |||||
| HL-60 | + | - | - | - | - | + | 12.0 | |||||
| ML-1 | + | - | - | + | - | + | 46.2 | |||||
| MOLM-1 | + | - | - | +++ | + | + | 40.8 | |||||
| K562 | - | - | - | - | - | + | 53.1 | |||||
| KG1a | + | - | - | + | - | + | 19.4 | |||||
| EM2 | + | - | - | - | - | + | 24.1 | |||||
| HEL | ± | - | - | - | - | + | 31.3 | |||||
| WSU-NHL | + | - | - | + | - | + | 68.2 | |||||
| U937 | + | - | - | - | - | + | 43.8 | |||||
| EM3 | + | - | - | ++ | - | + | 17.7 | |||||
| EOL-1 | + | - | - | ++++ | + | + | 37.6 | |||||
| LAZ221 | + | - | - | - | - | + | 14.1 | |||||
| MV4-11 | - | + | - | ++ | + | + | 13.1 | |||||
| REH | + | - | - | ++++ | + | + | 36.7 | |||||
| BV173 | + | - | - | ++++ | + | + | 25.2 | |||||
ITD indicates FLT3/ITD mutation; D835, FLT3/D835 mutation; MFI, mean fluorescence intensity; P-FLT3, phosphorylated FLT3; FACS, fluorescence-activated cell sorting.