Table 1. Dose modifications for... | American Society of Hematology

Table 1.

Dose modifications for nonhematologic toxicities

Grade 2	Grade 3/4
Interrupt treatment until recovery (≤ grade 1)	Interrupt treatment until recovery (≤ grade 1)
↓	↓
Resume at same doses	Resume full dose imatinib mesylate
↓	Reduce Ara-C to 10 mg/m²
If grade 2 recurs	↓
↓	If grade 3/4 recurs
Interrupt treatment until recovery (≤ grade 1)	↓
↓	Resume full dose imatinib mesylate reduce Ara-C to 5 mg/m²
Resume full dose imatinib mesylate
Reduce Ara-C to 10 mg/m²	↓
↓	If grade 3/4 recurs
If grade 2 recurs	↓
↓	Interrupt treatment until recovery (≤ grade 1)
Interrupt treatment until recovery (≤ grade 1)	↓
↓	Resume full dose imatinib mesylate
Resume full dose imatinib mesylate	STOP Ara-C
Reduce Ara-C to 5 mg/m²	↓
↓	If grade 3/4 recurs
If grade 2 recurs	↓
↓	Interrupt treatment until recovery (≤ grade 1)
Interrupt treatment until recovery (≤ grade 1)	↓
↓	Reduce imatinib mesylate to 300 mg
Reduce dose imatinib mesylate to 300 mg	↓
Reduce Ara-C to 5 mg/m²	If grade 3/4 recurs
↓	↓
If grade 2 recurs	Interrupt treatment until recovery (≤ grade 1)
↓	↓
Interrupt treatment until recovery (≤ grade 1)	Contact principal investigator to discuss further reduction of imatinib mesylate dose or discontinuation of all study drugs
↓
Resume imatinib mesylate at 300 mg
STOP Ara-C
↓
If grade 2 recurs
↓
Interrupt treatment until recovery (≤ grade 1)
↓
Contact principal investigator to discuss further reduction of imatinib mesylate dose or discontinuation of all study drugs

Grade 2	Grade 3/4
Interrupt treatment until recovery (≤ grade 1)	Interrupt treatment until recovery (≤ grade 1)
↓	↓
Resume at same doses	Resume full dose imatinib mesylate
↓	Reduce Ara-C to 10 mg/m²
If grade 2 recurs	↓
↓	If grade 3/4 recurs
Interrupt treatment until recovery (≤ grade 1)	↓
↓	Resume full dose imatinib mesylate reduce Ara-C to 5 mg/m²
Resume full dose imatinib mesylate
Reduce Ara-C to 10 mg/m²	↓
↓	If grade 3/4 recurs
If grade 2 recurs	↓
↓	Interrupt treatment until recovery (≤ grade 1)
Interrupt treatment until recovery (≤ grade 1)	↓
↓	Resume full dose imatinib mesylate
Resume full dose imatinib mesylate	STOP Ara-C
Reduce Ara-C to 5 mg/m²	↓
↓	If grade 3/4 recurs
If grade 2 recurs	↓
↓	Interrupt treatment until recovery (≤ grade 1)
Interrupt treatment until recovery (≤ grade 1)	↓
↓	Reduce imatinib mesylate to 300 mg
Reduce dose imatinib mesylate to 300 mg	↓
Reduce Ara-C to 5 mg/m²	If grade 3/4 recurs
↓	↓
If grade 2 recurs	Interrupt treatment until recovery (≤ grade 1)
↓	↓
Interrupt treatment until recovery (≤ grade 1)	Contact principal investigator to discuss further reduction of imatinib mesylate dose or discontinuation of all study drugs
↓
Resume imatinib mesylate at 300 mg
STOP Ara-C
↓
If grade 2 recurs
↓
Interrupt treatment until recovery (≤ grade 1)
↓
Contact principal investigator to discuss further reduction of imatinib mesylate dose or discontinuation of all study drugs