Oncoretroviral marking is higher in baboon SRCs than in autologous repopulating cells
. | Marking in baboons . | . | . | Mean SRC engraftment, % . | Marking in SRCs, % . | ||
|---|---|---|---|---|---|---|---|
| Animal . | 2 wk, % . | 6 wk, % . | 18 mo, % . | . | . | ||
| F99070 | 4.9 | ||||||
| PhoenixG | 33.8 | 7.3 | 4.8 | 54 | |||
| PG13 | 13.7 | 3.8 | 2.9 | 29 | |||
| 00021 | 2.6 | ||||||
| PhoenixG | 16.0 | 7.7 | 6.4 | 60 | |||
| PG13 | 4.3 | 2.6 | 3.7 | 45 | |||
| A00066 | 4.8 | ||||||
| PhoenixG | 29.1 | 4.4 | NA | 61 | |||
| PG13 | 16.0 | 2.4 | NA | 45 | |||
. | Marking in baboons . | . | . | Mean SRC engraftment, % . | Marking in SRCs, % . | ||
|---|---|---|---|---|---|---|---|
| Animal . | 2 wk, % . | 6 wk, % . | 18 mo, % . | . | . | ||
| F99070 | 4.9 | ||||||
| PhoenixG | 33.8 | 7.3 | 4.8 | 54 | |||
| PG13 | 13.7 | 3.8 | 2.9 | 29 | |||
| 00021 | 2.6 | ||||||
| PhoenixG | 16.0 | 7.7 | 6.4 | 60 | |||
| PG13 | 4.3 | 2.6 | 3.7 | 45 | |||
| A00066 | 4.8 | ||||||
| PhoenixG | 29.1 | 4.4 | NA | 61 | |||
| PG13 | 16.0 | 2.4 | NA | 45 | |||
Displayed are, for each baboon, the percentage of transgene-expressing cells of both experimental arms in white blood cells at approximately 2 weeks, 6 weeks, and 18 months after transplantation, the mean engraftment of baboon NOD/SCID repopulating cells (SRCs) after 6 weeks, and the percentage of transgene-expressing baboon SRCs.
NA indicates not applicable: the animal was transferred to a different study and humanely killed 6 months after transplantation.