Detection of virus-specific CD8+ T-cell clonotypes in healthy donors and in alloSCT recipients
Study no. . | Viral peptide . | . | % Clonotype sequence within all TCR sequences of the same Vβ family (mo after alloSCT) . |
|---|---|---|---|
| 01 | |||
| Donor | HCMV pp65495-503 | Clone 1.1 | 14 (2 in the allograft) |
| Recipient | HCMV pp65495-503 | Clone 1.1 | 73 (1), 70 (3), 57 (5), 4 (13), 5 (15) |
| Donor | HCMV IE72198-207 | Clone 1.2 | 7 |
| Clone 1.4 | 0 | ||
| Recipient | HCMV IE72198-207 | Clone 1.2 | 5 (3), 6 (5) |
| Clone 1.4 | 0 (before), 0 (1), 0 (3), 3 (5), 2 (13), 2 (15) | ||
| 02 | |||
| Donor | HCMV pp65417-426 | Clone 2.1 | 2 |
| Recipient | HCMV pp65417-426 | Clone 2.1 | 0 (before), 4 (2), 3 (5), 4 (9), 7 (18) |
| Donor | EBV EBNA3C880-891 | Clone 2.3 | 0 |
| Recipient | EBV EBNA3C880-891 | Clone 2.3 | 0 (before), 0 (2), 2 (5), 1 (9), 4 (18) |
| 03 | |||
| Donor | HCMV pp65495-503 | Clone 3.1a | 18 |
| Recipient | HCMV pp65495-503 | Clone 3.1a | 0 (before), 35 (10), 44 (15), 77 (20), 39 (27), 14 (32) |
| 04 | |||
| Donor | HCMV pp65495-503 | Clone 4.1 | 4 |
| Clone 4.2 | 0 | ||
| Recipient | HCMV pp65495-503 | Clone 4.1 | 3 (72) |
| Clone 4.2 | 3 (72), 1 (84) | ||
| 05 | |||
| Donor | HCMV pp65495-503 | Clone 5.1 | ND |
| Clone 5.2 | 0 | ||
| Recipient | HCMV pp65495-503 | Clone 5.1 | 0 (3), 0 (5), 0 (7), 0 (9), 0 (12), 0 (18) |
| Recipient | HCMV pp65495-503 | Clone 5.2 | 0 (3), 0 (5), 0 (7), 0 (9), 1 (12), 3 (18), 3 (21) |
| 06 | |||
| Donor | HCMV pp65495-503 | Clone 6.1a | 11 |
| Donor | HCMV pp65495-503 | Clone 6.1b | 4 |
| Recipient | HCMV pp65495-503 | Clone 6.1a | 0 |
| Recipient | HCMV pp65495-503 | Clone 6.1b | 1, negative control 1, (72) |
| Donor | EBV EBNA3C281-290 | Clone 6.2 | 0 (72) |
| Recipient | EBV EBNA3C281-290 | Clone 6.2 | 16 (72) |
| 07 | |||
| Donor | HCMV pp65417-426 | Clone 7.1 | 7 |
| Recipient | HCMV pp65417-426 | Clone 7.1 | 0 (2), 0 (4), 0 (9), 0 (30) |
| Donor | EBV EBNA3C880-891 | Clone 7.2 | 8 |
| Recipient | EBV EBNA3C880-891 | Clone 7.2 | 7 (2), 2 (4), 1 (9), 1 (30) |
| 08 | |||
| Donor | HCMV pp65495-503 | Clone 8.1 | 8 |
| Recipient | HCMV pp65495-503 | Clone 8.1 | 6 (2), 7 (3), 10 (5) |
| 09 | |||
| Donor | EBV EBNA3C880-891 | Clone 9.1 | 5 (4 in the allograft) |
| Recipient | EBV EBNA3C880-891 | Clone 9.1 | 4 (4), 4 (5), 6 (9), 19 (12), 17 (18), 14 (30) |
| 10 | |||
| Donor | HCMV pp65495-503 | Clone 10.1 | 41 |
| Donor | HCMV pp65397-411 | Clone 10.2 | 62 |
| Recipient | HCMV pp65495-503 | Clone 10.1 | 0 (before), 0 (1), 0 (4) |
| Recipient | HCMV pp65397-411 | Clone 10.2 | 0 (before), 0 (1), 0 (4) |
Study no. . | Viral peptide . | . | % Clonotype sequence within all TCR sequences of the same Vβ family (mo after alloSCT) . |
|---|---|---|---|
| 01 | |||
| Donor | HCMV pp65495-503 | Clone 1.1 | 14 (2 in the allograft) |
| Recipient | HCMV pp65495-503 | Clone 1.1 | 73 (1), 70 (3), 57 (5), 4 (13), 5 (15) |
| Donor | HCMV IE72198-207 | Clone 1.2 | 7 |
| Clone 1.4 | 0 | ||
| Recipient | HCMV IE72198-207 | Clone 1.2 | 5 (3), 6 (5) |
| Clone 1.4 | 0 (before), 0 (1), 0 (3), 3 (5), 2 (13), 2 (15) | ||
| 02 | |||
| Donor | HCMV pp65417-426 | Clone 2.1 | 2 |
| Recipient | HCMV pp65417-426 | Clone 2.1 | 0 (before), 4 (2), 3 (5), 4 (9), 7 (18) |
| Donor | EBV EBNA3C880-891 | Clone 2.3 | 0 |
| Recipient | EBV EBNA3C880-891 | Clone 2.3 | 0 (before), 0 (2), 2 (5), 1 (9), 4 (18) |
| 03 | |||
| Donor | HCMV pp65495-503 | Clone 3.1a | 18 |
| Recipient | HCMV pp65495-503 | Clone 3.1a | 0 (before), 35 (10), 44 (15), 77 (20), 39 (27), 14 (32) |
| 04 | |||
| Donor | HCMV pp65495-503 | Clone 4.1 | 4 |
| Clone 4.2 | 0 | ||
| Recipient | HCMV pp65495-503 | Clone 4.1 | 3 (72) |
| Clone 4.2 | 3 (72), 1 (84) | ||
| 05 | |||
| Donor | HCMV pp65495-503 | Clone 5.1 | ND |
| Clone 5.2 | 0 | ||
| Recipient | HCMV pp65495-503 | Clone 5.1 | 0 (3), 0 (5), 0 (7), 0 (9), 0 (12), 0 (18) |
| Recipient | HCMV pp65495-503 | Clone 5.2 | 0 (3), 0 (5), 0 (7), 0 (9), 1 (12), 3 (18), 3 (21) |
| 06 | |||
| Donor | HCMV pp65495-503 | Clone 6.1a | 11 |
| Donor | HCMV pp65495-503 | Clone 6.1b | 4 |
| Recipient | HCMV pp65495-503 | Clone 6.1a | 0 |
| Recipient | HCMV pp65495-503 | Clone 6.1b | 1, negative control 1, (72) |
| Donor | EBV EBNA3C281-290 | Clone 6.2 | 0 (72) |
| Recipient | EBV EBNA3C281-290 | Clone 6.2 | 16 (72) |
| 07 | |||
| Donor | HCMV pp65417-426 | Clone 7.1 | 7 |
| Recipient | HCMV pp65417-426 | Clone 7.1 | 0 (2), 0 (4), 0 (9), 0 (30) |
| Donor | EBV EBNA3C880-891 | Clone 7.2 | 8 |
| Recipient | EBV EBNA3C880-891 | Clone 7.2 | 7 (2), 2 (4), 1 (9), 1 (30) |
| 08 | |||
| Donor | HCMV pp65495-503 | Clone 8.1 | 8 |
| Recipient | HCMV pp65495-503 | Clone 8.1 | 6 (2), 7 (3), 10 (5) |
| 09 | |||
| Donor | EBV EBNA3C880-891 | Clone 9.1 | 5 (4 in the allograft) |
| Recipient | EBV EBNA3C880-891 | Clone 9.1 | 4 (4), 4 (5), 6 (9), 19 (12), 17 (18), 14 (30) |
| 10 | |||
| Donor | HCMV pp65495-503 | Clone 10.1 | 41 |
| Donor | HCMV pp65397-411 | Clone 10.2 | 62 |
| Recipient | HCMV pp65495-503 | Clone 10.1 | 0 (before), 0 (1), 0 (4) |
| Recipient | HCMV pp65397-411 | Clone 10.2 | 0 (before), 0 (1), 0 (4) |
ND indicates not done.