Analysis of CYP1B1 expression
Tissue . | Expression . |
|---|---|
| Cancer | |
| Acute lymphocytic leukemia* | +++ |
| Acute myeloid leukemia* | +++ |
| Breast cancer*† | +++ |
| Colon carcinoma* | +++ |
| Esophagus carcinoma† | +++ |
| Lung cancer* | +++ |
| Lymphoma* | +++ |
| Multiple myeloma*‡ | +++ |
| Melanoma*‡ | +++ |
| Ovarian carcinoma*† | +++ |
| Rhabdomyosarcoma† | +++ |
| Normal | |
| Fallopian tube* | +++ |
| Breast* | ++ |
| Uterus (cervix, endometrium)* | ++ |
| Ureter* | ++ |
| Skin* | + |
| Prostate* | +/- |
| Pancreas* | +/- |
| Pituitary gland* | +/- |
| Colon* | +/- |
| Bladder* | +/- |
| Small intestine* | +/- |
| Thymus* | +/- |
| Adrenal gland* | - |
| Blood cells* | - |
| Bone marrow* | - |
| Cerebellum* | - |
| Cerebral cortex* | - |
| Eye (retinal)* | - |
| Heart* | - |
| Kidney (glomerulus, tubule)* | - |
| Liver* | - |
| Lung* | - |
| Lymph node* | - |
| Ovary* | - |
| Parathyroid* | - |
| Placenta* | - |
| Skeletal muscle* | - |
| Spinal cord* | - |
| Spleen* | - |
| Stomach* | - |
| Testis* | - |
| Thyroid* | - |
Tissue . | Expression . |
|---|---|
| Cancer | |
| Acute lymphocytic leukemia* | +++ |
| Acute myeloid leukemia* | +++ |
| Breast cancer*† | +++ |
| Colon carcinoma* | +++ |
| Esophagus carcinoma† | +++ |
| Lung cancer* | +++ |
| Lymphoma* | +++ |
| Multiple myeloma*‡ | +++ |
| Melanoma*‡ | +++ |
| Ovarian carcinoma*† | +++ |
| Rhabdomyosarcoma† | +++ |
| Normal | |
| Fallopian tube* | +++ |
| Breast* | ++ |
| Uterus (cervix, endometrium)* | ++ |
| Ureter* | ++ |
| Skin* | + |
| Prostate* | +/- |
| Pancreas* | +/- |
| Pituitary gland* | +/- |
| Colon* | +/- |
| Bladder* | +/- |
| Small intestine* | +/- |
| Thymus* | +/- |
| Adrenal gland* | - |
| Blood cells* | - |
| Bone marrow* | - |
| Cerebellum* | - |
| Cerebral cortex* | - |
| Eye (retinal)* | - |
| Heart* | - |
| Kidney (glomerulus, tubule)* | - |
| Liver* | - |
| Lung* | - |
| Lymph node* | - |
| Ovary* | - |
| Parathyroid* | - |
| Placenta* | - |
| Skeletal muscle* | - |
| Spinal cord* | - |
| Spleen* | - |
| Stomach* | - |
| Testis* | - |
| Thyroid* | - |
For normal tissues, tissue sections from 3 subjects were evaluated for CYP1B1 expression. Breast carcinoma was used as a positive control, always showing high expression. +++ indicates more than 20% of cells with high expression in all 3 normal samples; ++, intermediate expression, or less than 20% of cells with high expression in at least one sample; +, low expression, or less than 20% of cells with intermediate expression in at least one sample; +/-, weak expression in at least one sample; and -, no expression in any sample tested.
Tissues analyzed by immunohistochemistry (IHC).
Tissues analyzed by Western blot.
Analysis not performed on primary tumor tissue.