Frequency of bleeding events per year in nontolerized hemophilia B dogs treated on demand and in tolerized hemophilia B dogs on chronic subcutaneous prophylactic rhFIX replacement therapy
. | Bleeding events per year . | . | |
|---|---|---|---|
| Hemophilia B dogs . | 0-1 y* . | 1-3.5 y† . | |
| Nontolerized (n) | 5.5 ± 3.3 (10) | 4.1 ± 3.6 (6) | |
| Tolerized (n) | 1.8 ± 0.5 (5) | 2.1 ± 1.0 (4) | |
| Reduction, % | 69 | 49 | |
| P‡ | .0007 | .44 | |
. | Bleeding events per year . | . | |
|---|---|---|---|
| Hemophilia B dogs . | 0-1 y* . | 1-3.5 y† . | |
| Nontolerized (n) | 5.5 ± 3.3 (10) | 4.1 ± 3.6 (6) | |
| Tolerized (n) | 1.8 ± 0.5 (5) | 2.1 ± 1.0 (4) | |
| Reduction, % | 69 | 49 | |
| P‡ | .0007 | .44 | |
Average number of bleeding events per year in the nontolerized and tolerized hemophilia B dogs during the first year of life.
Average number of bleeds per year in the tolerized hemophilia B dogs between the end of year 1 and the end of the study at 3.5 years.
P was determined by exact Wilcoxon rank sum test.