Comparison of gene structure between JAM family members
HGNC exon . | No. . | JAM-1 1q21.2-21.3 . | i . | JAM-2 21q21.2 . | i . | JAM-3 11q25 . | i . | JAML 11q23.3 . | i . |
|---|---|---|---|---|---|---|---|---|---|
| 5′ | 0 | — | — | — | — | — | — | >73 | — |
| Intron | 0-1 | — | — | — | — | — | — | 10 054 | — |
| ATG/signal sequence | 1 | 103 | — | >301 | — | >76 | — | 64 | — |
| Intron | 1-2 | 44 222 | 1 | 43 994 | 1 | 79 105 | 1 | 2262 | 1 |
| EC, Ig-fold 1 | 2 | 59 | — | 66 | — | 66 | — | — | — |
| Intron | 2-3 | 167 | 1 | 5916 | 1 | 740 | 1 | — | — |
| EC, Ig-fold 1 | 3 | 98 | — | 108 | — | 114 | — | 153 | — |
| Intron | 3-4 | 252 | 1 | 3782 | 1 | 3470 | 1 | 1694 | 1 |
| EC, Ig-fold 1 | 4 | 137 | — | 153 | — | 153 | — | 228 | — |
| Intron | 4-5 | 282 | 1 | 4768 | 1 | 398 | 1 | 4493 | 1 |
| EC, Ig-fold 2 | 5 | 203 | — | 203 | — | 203 | — | 110 | — |
| Intron | 5-6 | 167 | 0 | 3290 | 0 | 951 | 0 | 2217 | 0 |
| EC, Ig-fold 2 | 6 | 103 | — | 100 | — | 100 | — | 238 | — |
| Intron | 6-7 | 128 | 1 | 3709 | 1 | 2511 | 1 | 2815 | 1 |
| Transmembrane | 7 | 108 | — | 108 | — | 130 | — | 137 | — |
| Intron | 7-8 | 231 | 1 | 3347 | 1 | — | — | 2384 | 1 |
| IC | 8 | 13 | — | 16 | — | — | — | 95 | — |
| Intron | 8-9 | 304 | 2 | 2890 | 2 | 87 | 2 | 1176 | 2 |
| IC | 9 | 49 | — | 43 | — | 55 | — | 88 | — |
| Intron | 9-10 | 136 | 0 | 2257 | 0 | 321 | 0 | 2318 | 0 |
| IC/STOP | 10 | >937 | — | >283 | — | >36 | — | >452 | — |
HGNC exon . | No. . | JAM-1 1q21.2-21.3 . | i . | JAM-2 21q21.2 . | i . | JAM-3 11q25 . | i . | JAML 11q23.3 . | i . |
|---|---|---|---|---|---|---|---|---|---|
| 5′ | 0 | — | — | — | — | — | — | >73 | — |
| Intron | 0-1 | — | — | — | — | — | — | 10 054 | — |
| ATG/signal sequence | 1 | 103 | — | >301 | — | >76 | — | 64 | — |
| Intron | 1-2 | 44 222 | 1 | 43 994 | 1 | 79 105 | 1 | 2262 | 1 |
| EC, Ig-fold 1 | 2 | 59 | — | 66 | — | 66 | — | — | — |
| Intron | 2-3 | 167 | 1 | 5916 | 1 | 740 | 1 | — | — |
| EC, Ig-fold 1 | 3 | 98 | — | 108 | — | 114 | — | 153 | — |
| Intron | 3-4 | 252 | 1 | 3782 | 1 | 3470 | 1 | 1694 | 1 |
| EC, Ig-fold 1 | 4 | 137 | — | 153 | — | 153 | — | 228 | — |
| Intron | 4-5 | 282 | 1 | 4768 | 1 | 398 | 1 | 4493 | 1 |
| EC, Ig-fold 2 | 5 | 203 | — | 203 | — | 203 | — | 110 | — |
| Intron | 5-6 | 167 | 0 | 3290 | 0 | 951 | 0 | 2217 | 0 |
| EC, Ig-fold 2 | 6 | 103 | — | 100 | — | 100 | — | 238 | — |
| Intron | 6-7 | 128 | 1 | 3709 | 1 | 2511 | 1 | 2815 | 1 |
| Transmembrane | 7 | 108 | — | 108 | — | 130 | — | 137 | — |
| Intron | 7-8 | 231 | 1 | 3347 | 1 | — | — | 2384 | 1 |
| IC | 8 | 13 | — | 16 | — | — | — | 95 | — |
| Intron | 8-9 | 304 | 2 | 2890 | 2 | 87 | 2 | 1176 | 2 |
| IC | 9 | 49 | — | 43 | — | 55 | — | 88 | — |
| Intron | 9-10 | 136 | 0 | 2257 | 0 | 321 | 0 | 2318 | 0 |
| IC/STOP | 10 | >937 | — | >283 | — | >36 | — | >452 | — |
HGNC indicates HUGO Nomenclature Committee; i, phase of introns; EC, extracellular domain; IC, intracellular domain; and Ig-fold, immunoglobulin-like fold.