Baseline characteristics of patients with severe sepsis by Leiden mutation status in the PROWESS study*
Baseline characteristics . | VL+/- patients (n = 65) . | VL-/- patients (n = 1536) . | P . |
|---|---|---|---|
| Demographics | |||
| Age, y | 63.16 ± 14.92 | 60.54 ± 16.79 | .27 |
| Male sex, % | 58.46 | 57.03 | .898 |
| Caucasian race, % | 93.85 | 81.64 | .008 |
| Prior or pre-existing conditions, % | |||
| Hypertension | 32.31 | 36.91 | .512 |
| Myocardial infarction | 12.31 | 13.48 | 1.00 |
| Congestive cardiomyopathy | 6.15 | 7.55 | 1.00 |
| Diabetes | 21.54 | 21.22 | 1.00 |
| Pancreatitis | 3.08 | 3.84 | 1.00 |
| Liver disease | 0.0 | 2.47 | .401 |
| Chronic obstructive pulmonary disease | 29.23 | 23.96 | .374 |
| Cancer | 24.62 | 17.64 | .184 |
| Recent trauma | 1.54 | 4.17 | .516 |
| Recent surgical history | 36.92 | 29.56 | .214 |
| Indicator of disease severity | |||
| APACHE II score | 24.86 ± 8.05 | 24.75 ± 7.71 | .825 |
| Shock, % | 69.23 | 71.16 | .780 |
| Use of any vasopressor, % | 46.15 | 62.96 | .009 |
| SOFA (cardiovascular) | 2.29 ± 0.184 | 2.66 ± 0.038 | .052 |
| Overt disseminated intravascular coagulation,† % | 23.08 | 22.01 | .879 |
| No. of dysfunctional organs, % | .815 | ||
| 1 | 21.54 | 24.67 | |
| 2 | 32.31 | 32.42 | |
| 3 or more | 46.15 | 42.90 | |
| Site of infection,‡% | .592 | ||
| Intra-abdominal | 24.62 | 20.18 | |
| Lung | 55.38 | 53.26 | |
| Urinary tract | 6.15 | 10.16 | |
| Other§ | 13.85 | 16.41 | |
| Infection type,∥% | .425 | ||
| Pure gram positive | 24.62 | 25.39 | |
| Pure gram negative | 26.15 | 23.44 | |
| Mixed gram | 18.46 | 10.94 | |
| Pure nonbacteria | 3.08 | 3.06 | |
| Mixed organisms | 1.54 | 2.67 | |
| Unknown | 26.1 | 34.51 |
Baseline characteristics . | VL+/- patients (n = 65) . | VL-/- patients (n = 1536) . | P . |
|---|---|---|---|
| Demographics | |||
| Age, y | 63.16 ± 14.92 | 60.54 ± 16.79 | .27 |
| Male sex, % | 58.46 | 57.03 | .898 |
| Caucasian race, % | 93.85 | 81.64 | .008 |
| Prior or pre-existing conditions, % | |||
| Hypertension | 32.31 | 36.91 | .512 |
| Myocardial infarction | 12.31 | 13.48 | 1.00 |
| Congestive cardiomyopathy | 6.15 | 7.55 | 1.00 |
| Diabetes | 21.54 | 21.22 | 1.00 |
| Pancreatitis | 3.08 | 3.84 | 1.00 |
| Liver disease | 0.0 | 2.47 | .401 |
| Chronic obstructive pulmonary disease | 29.23 | 23.96 | .374 |
| Cancer | 24.62 | 17.64 | .184 |
| Recent trauma | 1.54 | 4.17 | .516 |
| Recent surgical history | 36.92 | 29.56 | .214 |
| Indicator of disease severity | |||
| APACHE II score | 24.86 ± 8.05 | 24.75 ± 7.71 | .825 |
| Shock, % | 69.23 | 71.16 | .780 |
| Use of any vasopressor, % | 46.15 | 62.96 | .009 |
| SOFA (cardiovascular) | 2.29 ± 0.184 | 2.66 ± 0.038 | .052 |
| Overt disseminated intravascular coagulation,† % | 23.08 | 22.01 | .879 |
| No. of dysfunctional organs, % | .815 | ||
| 1 | 21.54 | 24.67 | |
| 2 | 32.31 | 32.42 | |
| 3 or more | 46.15 | 42.90 | |
| Site of infection,‡% | .592 | ||
| Intra-abdominal | 24.62 | 20.18 | |
| Lung | 55.38 | 53.26 | |
| Urinary tract | 6.15 | 10.16 | |
| Other§ | 13.85 | 16.41 | |
| Infection type,∥% | .425 | ||
| Pure gram positive | 24.62 | 25.39 | |
| Pure gram negative | 26.15 | 23.44 | |
| Mixed gram | 18.46 | 10.94 | |
| Pure nonbacteria | 3.08 | 3.06 | |
| Mixed organisms | 1.54 | 2.67 | |
| Unknown | 26.1 | 34.51 |
Where applicable, results are means ± SD. Because of rounding, not all percentages total 100.
Overt DIC was defined according to the definition of the International Society on Thrombosis and Haemostasis.48
The site of infection was presumed on the basis of clinical findings.
Other sites of infection included the blood, skin, central nervous system, bones and joints, cardiac system, head/eyes, ears, nose and throat, pleural, vascular catheter, and reproductive organs.
Patients may have had more than one organism cultured. Classification of infection type is based on adjudication from the clinical evaluation committee.