Role of AP1/NFE2 binding sites in α-globin expression
. | α-globinnonAKR/α-globinAKRexpression, % . | . | . | ||
|---|---|---|---|---|---|
| HS-26 test allele . | Fetal liver, E 14.5 . | Adult bone marrow . | Adult blood . | ||
| Wild type | 93 ± 4 | 106 ± 2 | 95 ± 6 | ||
| n = 19* | n = 4* | n = 13* | |||
| Floxed | 22 ± 2 | 28 ± 2 | 37 ± 4 | ||
| n = 6 | n = 4 | n = 7 | |||
| ΔNFE2 | 70 ± 4 | 69 ± 2 | 81 ± 4 | ||
| n = 10* | n = 4* | n = 8* | |||
. | α-globinnonAKR/α-globinAKRexpression, % . | . | . | ||
|---|---|---|---|---|---|
| HS-26 test allele . | Fetal liver, E 14.5 . | Adult bone marrow . | Adult blood . | ||
| Wild type | 93 ± 4 | 106 ± 2 | 95 ± 6 | ||
| n = 19* | n = 4* | n = 13* | |||
| Floxed | 22 ± 2 | 28 ± 2 | 37 ± 4 | ||
| n = 6 | n = 4 | n = 7 | |||
| ΔNFE2 | 70 ± 4 | 69 ± 2 | 81 ± 4 | ||
| n = 10* | n = 4* | n = 8* | |||
Values presented as ± SD.
t test; P < .001.