Table 1.

Pretreatment characteristics of 15 patients with relapsed or refractory HCL

Patient no.
Age, y/sex
Prior therapy
Time from diagnosis, mo
Granulocytes, × 109/L
Hgb, g/dL
Platelets, × 109/L
Absolute CD4 count
β2-microglobulin, mg/dL
1   60/M   IFN-α, 2-CdA × 2   103   3.6   13.4   196   484   2.6  
2   47/M   Splenectomy, DCF   72   1.1   7.2   311   343   1.4  
3   66/F   2-CdA   111   1.5   11.7   92   474   2.3  
4   49/M   2-CdA   80   2.9   15.9   167   481   1.3  
5   44/M   2-CdA   39   2.2   13.4   231   595   1.7  
6   41/F   2-CdA   72   1.2   13.0   75   569   1.5  
7   35/M   2-CdA   4   0.1   9.2   59   —   1.4  
8   60/M   2-CdA × 2, splenectomy, IFN-α   72   0.6   10.0   104   —   3.3  
9   52/M   DCF, IFN-α, fludarabine, 2-CdA × 3   84   1.1*  12.2   103   119   1.5  
10   58/M   IFN-α, 2-CdA, IFN-α, 2-CdA   126   1.2   11.2   88   —   —  
11   59/M   2-CdA   107   1.3   11.4   99   306   1.5  
12   71/F   2-CdA × 2   46   2.3*  10.6   90   260   3.7  
13   28/M   2-CdA   6   1.5*  14.8   79   1430   1.7  
14   63/M   2-CdA   106   0.1   7.2   29   225   3.9  
15
 		 65/M
 		 Splenectomy, IFN-α, DCF, 2-CdA
 		 225
 		 0.9
 		 13.4
 		 121
 		 —
 		 1.8
 
Patient no.
Age, y/sex
Prior therapy
Time from diagnosis, mo
Granulocytes, × 109/L
Hgb, g/dL
Platelets, × 109/L
Absolute CD4 count
β2-microglobulin, mg/dL
1   60/M   IFN-α, 2-CdA × 2   103   3.6   13.4   196   484   2.6  
2   47/M   Splenectomy, DCF   72   1.1   7.2   311   343   1.4  
3   66/F   2-CdA   111   1.5   11.7   92   474   2.3  
4   49/M   2-CdA   80   2.9   15.9   167   481   1.3  
5   44/M   2-CdA   39   2.2   13.4   231   595   1.7  
6   41/F   2-CdA   72   1.2   13.0   75   569   1.5  
7   35/M   2-CdA   4   0.1   9.2   59   —   1.4  
8   60/M   2-CdA × 2, splenectomy, IFN-α   72   0.6   10.0   104   —   3.3  
9   52/M   DCF, IFN-α, fludarabine, 2-CdA × 3   84   1.1*  12.2   103   119   1.5  
10   58/M   IFN-α, 2-CdA, IFN-α, 2-CdA   126   1.2   11.2   88   —   —  
11   59/M   2-CdA   107   1.3   11.4   99   306   1.5  
12   71/F   2-CdA × 2   46   2.3*  10.6   90   260   3.7  
13   28/M   2-CdA   6   1.5*  14.8   79   1430   1.7  
14   63/M   2-CdA   106   0.1   7.2   29   225   3.9  
15
 		 65/M
 		 Splenectomy, IFN-α, DCF, 2-CdA
 		 225
 		 0.9
 		 13.4
 		 121
 		 —
 		 1.8
 

Patient nos. 2 and 14 both transfusion-dependent of packed red blood cells, with the latter also platelet transfusion dependent. Patient nos. 6, 7, 8, and 12 had splenomegaly more than 5 cm below costal margin. 2-CdA × denotes number of salvage attempts with 2-CdA; and —, not done.

*

Circulating hairy cells

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