Table 4.

Risk factors for developing LONIPCs



All patients

LONIPC patients

Factor
n
%
n
%
P
Sex: male vs female   52 of 76   68.4   12 of 18   66.7   NS  
Source       
Related PBSCs vs BM   18 of 27   66.7   6 of 7   85.7   NS  
Unrelated BM vs related BM   47 of 56   83.9   11 of 12   91.7   NS  
HLA compatibility: mismatch vs full match   17 of 76   22.4   4 of 18   22.2   NS  
Blood type mismatch: + vs −   28 of 76   36.8   5 of 18   27.8   NS  
Sex mismatch: + vs −   29 of 76   38.2   7 of 18   38.9   NS  
Conditioning: TBI/TLI vs non-TBI/TLI   35 of 76   46.1   11 of 18   61.1   NS  
GVHD prophylaxis: CsA vs FK506   60 of 76   78.9   16 of 18   88.9   NS  
Acute GVHD: II-IV vs 0/I   29 of 76   38.2   8 of 18   44.4   NS  
Chronic GVHD: extensive vs 0/limited   37 of 76   48.7   15 of 18   83.3   .0008  
Liver: + vs −   32 of 76   42.1   9 of 18   50.0   NS  
Skin: + vs −   35 of 76   46.1   10 of 18   55.6   NS  
Sicca syndrome: + vs −   33 of 76   43.4   15 of 18   83.3   <.0001  
Disease status: high vs standard
 
38 of 69
 
55.1
 
14 of 17
 
82.4
 
.0092
 


All patients

LONIPC patients

Factor
n
%
n
%
P
Sex: male vs female   52 of 76   68.4   12 of 18   66.7   NS  
Source       
Related PBSCs vs BM   18 of 27   66.7   6 of 7   85.7   NS  
Unrelated BM vs related BM   47 of 56   83.9   11 of 12   91.7   NS  
HLA compatibility: mismatch vs full match   17 of 76   22.4   4 of 18   22.2   NS  
Blood type mismatch: + vs −   28 of 76   36.8   5 of 18   27.8   NS  
Sex mismatch: + vs −   29 of 76   38.2   7 of 18   38.9   NS  
Conditioning: TBI/TLI vs non-TBI/TLI   35 of 76   46.1   11 of 18   61.1   NS  
GVHD prophylaxis: CsA vs FK506   60 of 76   78.9   16 of 18   88.9   NS  
Acute GVHD: II-IV vs 0/I   29 of 76   38.2   8 of 18   44.4   NS  
Chronic GVHD: extensive vs 0/limited   37 of 76   48.7   15 of 18   83.3   .0008  
Liver: + vs −   32 of 76   42.1   9 of 18   50.0   NS  
Skin: + vs −   35 of 76   46.1   10 of 18   55.6   NS  
Sicca syndrome: + vs −   33 of 76   43.4   15 of 18   83.3   <.0001  
Disease status: high vs standard
 
38 of 69
 
55.1
 
14 of 17
 
82.4
 
.0092
 

NS indicates not significant.

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