List of genes and gene categories induced by LMP2A
Murine bone marrow CD19+ . | Murine spleen CD19+ . | Human BJAB + LMP2A . | Human LCL + LMP2A . |
|---|---|---|---|
| Cell cycle/apoptosis | |||
| Baculoviral IAP repeat-containing 5 (survivin) | CT-2, cell cycle/apoptosis inhibitor 6 (Api6) | Nuclear mitotic apparatus protein 1 (Numa 1) | Cyclin F |
| Cyclin D 1 | Bcl-xL | Programmed cell death 6 (Pdcd6) | Cyclin I |
| Cyclin-dependent kinase 5 (cdk5) | Baculoviral IAP repeat-containing 5 (survivin) | Cysteine-rich protein, nucleolar (Hsa6591) | |
| Cyclin-dependent kinase 9 (Cdk9) | B-cell translocation gene 3 (Btg3) | Polo-like kinase (Plk) | |
| Inhibin beta E (Inhbe) | Caspase-11 | Rcl, c-myc responsive | |
| Leukemia inhibitory factor receptor (Lifr) | Caspase-3 | Circadian oscillary protein (Scop) | |
| Proliferating cell nuclear antigen (PCNA) | Cdc20 | ||
| Prolactin-like protein A (Prlpa) | Cell division cycle 2 homolog A (Cdc2a) | ||
| Prothymosin alpha (Ptma) | Cell division cycle 6 homolog (Cdc6) | ||
| TOB3 | CDC28 protein kinase 1 (Cks 1) | ||
| Cytochrome c-1 (Cyc 1) | |||
| Cyclin A2 | |||
| Cyclin B2 | |||
| Geminin (Gmnn) | |||
| MAD2 (mitotic arrest deficient)-like 1 (mad211) | |||
| Antigen identified by monoclonal antibody Ki 67 | |||
| Protein regulator of cytokinesis 1-like (Prc 1) | |||
| Neural stem cell-derived neuronal survival (Sdnsf) | |||
| Serine (or cysteine) proteinase inhibitor (Serpinb6) | |||
| Cd27 binding protein (Hindu God of destruction, Siva) | |||
| DNA/RNA metabolism | |||
| Apoptotic chromatin condensation ind in nucleus (Acinus) | Brain abundant, membrane-attached signal protein 1 (Basp 1) | Eukaryotic translation initiation factor 4 gamma (elF4g1) | BAF53A, chromatin remodeling |
| Absent, small, or homeotic discs 1 (Ash 1) | Eukaryotic translation elongation factor 1 delta (Eefld) | Histone family member H2B/S | Centromere protein A (Cenpa) |
| D-E-A-D box polypeptide 6 (Dbp6) | Eukaryotic translation initiation factor 3, subunit 7 (elF3s7) | H2B histone family, member H2BFS | elF-3s8 |
| Excision repair cross-comp repair deficiency (Ercc2) | ELL-related RNA polymerase II (E112) | H4 histone family, member H4FG | Glycyl-tRNA synthetase (Gars) |
| General control of amino acid synthesis-like 2 (Gen512) | High-mobility group box 2 nuclear protein (Hmgb2) | Polymerase (DNA directed), mu (Polm) | Histone H1x (H1fx) |
| General transcription factor III A (Gtf3a) | High-mobility group nucleosomal binding domain 2 (Hmgn2) | RNA binding motif, ss interacting protein (MSSP-1, Rbms 1) | IGF-II mRNA-binding protein 3 (Koc1) |
| H3 histone, family 3A (H3f3a) | Hn ribonucleoproteins methyltransferase-like 2 (Hhmr112) | Ribosomal protein S11 | Mitochondrial ribosomal protein S27 (Mrps27) |
| High mobility group nucleosomal binding domain 2 (Hmgn2) | Eukaryotic translation initiation factor 1A (IFly) | 40S ribosomal protein SA (Rsp4) | 8-oxoguanine DNA glycosylase (Oggl) |
| Mini chromosome maintenance-deficient 4 homolog (Mcmd4) | Mini chromosome maintenance deficient (Mcmd) | Splicing factor 3a, subunit 2 (Sf3a2) | DNA polymerase delta small subunit (Polo2) |
| Polymerase (DNA directed) alpha 2 (Pola2) | MORF-related gene X (mrgx) | SWI/SNF related regulator of chromatin (Smarca4) | RNA polymerase II, polypeptide J (Polr2j) |
| Polymerase (DNA directed) mu (Polm) | Mitochondrial ribosomal protein L30 (Mrpl30) | SWI/SNF related regulator of chromatin (Smarcb 1) | Replication protein A3 (Rpa3) |
| RAD51-associated protein 1 (Rad51 ap 1) | Polymerase (DNA directed), alpha 2 (Pola2) | Transcription termination factor, RNA polymerase I (Ttf1) | Seryl-tRNA synthetase (Sars) |
| Ribosomal protein L32 | RNA binding motif protein 10 (Rbm 10) | Zinc-finger helicase (hZFH) | Small nuclear ribonucleoprotein polypeptides B and B1 (Snrpb) |
| Ribosomal protein L5 | RNA binding motif protein 3 (Rbm3) | Zinc finger protein 161 (Znf161) | Structure-specific recognition protein 1 (Ssrp 1) |
| Ribosomal protein L7 | RNA binding motif, ss interacting protein (MSSP-1, Rbms 1) | Zinc finger protein 220 (Znf220) | ATP-dependent mitochondrial RNA helicase (SUV3, Sars) |
| Ribosomal protein S26 | Ribosomal protein L22 | Transcription elongation factor A (SII, Tceal) | |
| Ribosomal protein S4, X-linked (Rps4x) | Ribosomal protein S6 kinase polypeptide 1 (Rps6ka1) | Topoisomerase (DNA) II alpha (Top2a) | |
| Suppressor of Ty 4 homolog (Spt4h) | Ribosome binding protein 1 (Rrbp 1) | UMP synthase (Umps) | |
| DNA/RNA metabolism (continued) | |||
| Xlr-related, meiosis regulated (Xmr) | Ribonucleotide reductase M1 (Rrm1) | Tyrosyl-tRNA synthetase (Yars) | |
| Tyrosyl-tRNA synthetase (Yars) | Ribonucleotide reductase M2 subunit (Rrm2) | Zinc finger protein 9 (Znf9) | |
| Zinc finger protein 125, (ZT2, Zfp 125) | Topoisomerase (DNA) II alpha (Top2a) | Eukaryotic translation termination factor 1 (Etf1) | |
| Zinc finger protein, multitype (FOG Friend of GATA, Zfpm1) | |||
| Inflammation/immunity | |||
| Allograft inflammatory factor 1 (lbal, Aif1) | Lipocortin 1, annexin A1 (Anxa1) | Ig alpha chain C region (Alc) | |
| Complement component 9 (C9) | B-cell-receptor gene (Bcr) | CD86 antigen (CD28 antigen ligand 2, B7-2) | |
| Calumenin (Calu) | Complement Clq B chain (Clqb) | C-type lectin, superfamily member 2 (Clecsf2) | |
| CD84 antigen | Complement component 1, q subcomponent, c (Clqc) | HCGII-7 hemochromatosis candidate genes | |
| Fibroblast growth factor 1 (Fgf1) | Calumenin, secretory pathway (Calu) | Regulatory factor X, 2 (Rfx2) | |
| Fibroblast growth factor 5 (Fgf5) | CD68 antigen | ||
| Interferon activated gene 204 (lfi204) | CD7 antigen | ||
| Germ line immunoglobulin V(H)II gene H8 | CD9 antigen | ||
| Interferon gamma-inducing factor binding protein (lgifbp) | Cathelin-like protein (CLP, CRAMP, Cnlp) | ||
| Immunoglobuling J chain | Cytokine receptor-like molecule (EB13), EBV-ind gene 3 | ||
| Immunoglobulin kappa chain variable 20 (V20 family) | Endoglin (Eng) | ||
| Interleukin-13 receptor, alpha 2 (IL-13a2) | Ficolin A (Fena) | ||
| Interleukin-5 (IL-5) | Histocompatibility 13 (H13) | ||
| Immunity-associated protein (Imap) | Histocompatibility 47 (H47) | ||
| Lymphocyte-activation gene 3 (Lag 3) | H-2 class I histocompatibility antigen (HA1D) | ||
| Lymphocyte antigen 6 complex, locus D (Ly-6d) | Ig heavy chain V region (MPC 11, HV01) | ||
| Reg factor X-ass ankyrin-containing protein (Rfxank) | Single chain antibody scFv (scFvCPSQ) | ||
| TNF receptor superfamily, member 8 (Tnfrsf8) | mRNA (IB5) for IgA V-D-J-heavy chain | ||
| Immunoglobulin heavy chain V region mRNA | |||
| Clone WS2a43 mutated immunoglobulin heavy chain | |||
| Immunoglobulin heavy chain 8 (heavy chain of IgG3) | |||
| Ig active joining chain (J chain) of the b allele | |||
| Immunoglobulin kappa light chain variable region | |||
| Immunoglobulin variable gene V kappa | |||
| Immunoglobulin light chain V region | |||
| Immunoglobulin light chain IgG | |||
| Anti-DNA immunoglobulin light chain IgG | |||
| Extrachromosomal DNA for V kappa and J k coding joint | |||
| Ig rearranged truncated mu-chain | |||
| IFN-stimulated protein, 20 kDa (Isg207) | |||
| Integral membrane protein 3 (Itm3) | |||
| Immunoglobulin J chain | |||
| Lymphocyte antigen 6 complex, locus C (Ly-6c) | |||
| Mannose receptor, C type 1 (Mrc1) | |||
| Intracellular ca-binding prot (MRP 14, calgranulin B, s100a9) | |||
| Secretory leukoprotease inhibitor gene (Slpi) | |||
| TGF beta 1 induced transcript 4 (Tgfbli4) | |||
| TNF receptor superfamily, member 17 (Tnfrsf17) | |||
| Vascular cell adhesion molecule 1 (Vcam1) | |||
| Signaling | |||
| Adrenergic receptor, beta 3 (Adrb3) | rhoB gene, ras homolog (Arhb) | Ras homolog gene family, member G (rho G Arhg) | Cornichon-like (Cnil) |
| Cadherin EGF LAG 7-pass G-type rec 2 (flamingo 1, Celsr2) | Arsenate resistance protein 2 (Acr2, Ars2) | Rho GDP dissociation inhibitor (GDI) alpha (Arhgdia) | Dual-specificity tyr-phosphorylation reg kinase 1A (Dyrk 1a) |
| Calcium and integrin binding 1 (calmyrin, KIP, Cib 1) | GP1-anchored membrane protein 1 (Gpiap 1) | GTP binding protein overexpressed in skeletal muscle (Gem) | FK506 binding protein 2 (Fkbp2) |
| Cytokine inducible SH2-containing protein (SOCS-1, Cis) | Gene trap locus 3, Delta-like Dlk1 (Gtl3) | 5-hydroxytryptamine (serotonin) receptor 1E (Htr1e) | Guanylate cyclase activator (Guca1b) |
| Creatine kinase, mitochondrial 1 (Ckmt 1) | Potentially oncogenic Ras (Ki-Ras) | Inositol 1,4,5-triphosphate receptor, type 1 (ltpr 1) | Hyaluronan-mediated motility receptor (RHAMM CD168, Hmmr) |
| Tyrosine protein kinase (Csk) | Kit oncogene | Mitogen-activated protein kinase kinase 2 (Map2k2) | Mitogen-act protein kinase kinase kinase kinase 1 (Map4k1) |
| Casein kinase 1, delta (Csnk 1d) | Membrane-spanning 4-domains (Ms4a6b) | Pecanex-like 3 (Penxl3) | Adaptor protein p 150, P13-kinase regulatory subunit 4 (Pik3r4) |
| Delta-like 1 (Dll 1) | Phosphatidylinositol-4-phosphate 5-kinase (Pip5k2a) | 3-phosphoinositide-dependent protein kinase-1 (Pdpk 1) | Protein phosphatase 1G (formerly 2C) (PPM1G) |
| Ectodermal-neural cortex 1 (Enc1) | Protein tyrosine phosphatase, nonreceptor type 8 (Ptpn8) | Protein phosphatase 3 (formerly 2B)(calcineurin A alpha) | Protein phosphatase 2 (formerly 2A)(Ppp2r2a) |
| FK506 binding protein 4 (Fkbp4) | Protein tyr pptase, nonreceptor type (SHPS, BIT, Ptpns 1) | RaP2 interacting protein 8, small GTPase int prot (Rpip8) | |
| Fyn-related kinase (Frk) | Sell (suppressor of lin-12) 1 homolog (Sel1h) | Sac domain-containing inositol phosphatase 3 (Sac3) | |
| Frizzled homolog 2 (Fzd2) | Signal-transducing adaptor molecule 1 (Stam 1) | Tyrosine kinase 2 (Tyk2) | |
| Frizzled homolog 8 (Fzd8) | WW domain binding protein 2 (Wbp2) | Unc-51-like kinase 1 (Ulk 1) | |
| Ras GTPase activating protein binding protein 1 (G3BP) | Zeta-chain (TCR)-associated protein kinase (Zap-70) | ||
| Growth hormone-inducible transmembrane protein (Ghitm) | |||
| Protein phosphatase 3, catalytic subunit (Ppp3ca) | |||
| Protein tyrosine phosphatase, receptor type (Ftp-1, Ptprl) | |||
| GTP binding nuclear protein (Ran) | |||
| Wingless related MMTV integration site 10b (Wnt10b) | |||
| Wingless-related MMTV integration site 6 (Wnt6) | |||
| Transcription factors | |||
| BarH-like homeobox 1 (Barx1) | Carbon catabolite repression 4 homolog (Ccr4) | Bromodomain-containing 3 (Brd3) | Leucine-zipper protein, repressor of cAMP, MAPK (Atf5) |
| Distal-less homeobox 2 (Dlx2) | CCAAT/enhancer binding protein (C/EBP) | BTB (POZ) domain-containing 3 (Btbd3) | Cellular repressor of E1A-stimulated genes (Creg) |
| GLI-Kruppel family member (Gli1) | Cellular repressor of E1A-stimulated genes (Creg) | Bithorax Bx1 homeobox (Bx1) | Alternatively spliced cut-like 1 (Cutl1) |
| H6 homeobox 3 repressor (Hmx3) | dbpA homologue, cold shock domain protein A (Csda6) | CCR4-NOT transcription complex, subunit 8 (Cnot8) | Forkhead protein (FKHRLI, Fox03a) |
| LIM homeobox protein 1 (Lhx1) | Transcription factor (Dp 1) | NFk light polypeptide enhancer in B cells inhibitor (nfkbia) | |
| Similar to zinc finger protein pMLZ-4 (Mlz-4) | ets variant gene 6 (TEL, Etv6) | PR domain-containing 2, with ZNF domain (Prdm2) | |
| Myogenin (Myog) | Ewing sarcoma homolog (Ews) | Sirtuin silent mating type information reg 2 homolog 6 (Sirt6) | |
| Y-box binding protein (oxyR) | Enhancer of zeste homolog 2 (Ezh2) | SP140 nuclear body protein | |
| Paired box gene 3 (Pax3) | HIV type 1 enhancer binding protein 1 (Hivep 1) | ||
| Norepinephrine transporter (SLC6A5) | Inhibitor protein (Id2) | ||
| T-cell factor-1 (Tcf-1) | Makorin, ring finger protein, (Mkm1) | ||
| Transcription factor AP-2 beta (Tcfap2b) | T-cell acute leukemia 1 (Tal1) | ||
| Transcription factor 7 (Tcf7) | |||
| X-box binding protein 1 (Xbp1) | |||
| Tumor-associated | |||
| ElaC homolog 2 (Elac2) | Arginine-rich, mutated in early stage tumors (Armet) | HLA-B-associated transcript 3 (Bat3) | |
| Leukemia-associated gene (Pr22, Lag) | Ecotropic viral integration site 2 (Evi2) | Prostate tumor overexpressed gene 1 (Ptov 1) | |
| Neoplastic progression 2 (Npn2) | Immunoglobulin superfamily, member 4 (TSLC1, Igsf4) | ||
| Gene overexpressed in astrocytoma (Goa, Oea) | Leukemia-associated gene (Lag) | ||
| Proviral integration site 1 (Pim 1) | Expressed in nonmetastatic cells 3 (Nme3) | ||
| T-cell leukemia/lymphoma 1B (Tcl 1 bl) | Protein-serine/threonine kinase (Pim2) | ||
| Secreted acidic cys-rich glycoprotein/osteonectin (Sparc) | |||
| Ubiquitination | |||
| Proteasome (prosome, macropain) 26S subunit (psmd3) | Proteasome (prosome, macropain) subunit (Psma4) | F-box and leucine-rich repeat protein 7 (Fb17) | Proteasome (prosome, macropain) 26S subunit (Psmd8) |
| WW domain-containing protein 4 (Wwp2) | Proteasome (prosome, macropain) 26S subunit (psmc2) | Proteasome (prosome, macropain) subunit (Psmb9) | Ubiquitin-conjugating enzyme E2C (Ube2c) |
| Proteasome (prosome, macropain) 26S subunit (Psmd11) | Ubiquitin-conjugating enzyme E21 (UBC9, Ube21) | ||
| Ubiquitin fusion degradation 1-like (Ufd 11) | Ubiquitin-specific protease 22 (Usp22) |
Murine bone marrow CD19+ . | Murine spleen CD19+ . | Human BJAB + LMP2A . | Human LCL + LMP2A . |
|---|---|---|---|
| Cell cycle/apoptosis | |||
| Baculoviral IAP repeat-containing 5 (survivin) | CT-2, cell cycle/apoptosis inhibitor 6 (Api6) | Nuclear mitotic apparatus protein 1 (Numa 1) | Cyclin F |
| Cyclin D 1 | Bcl-xL | Programmed cell death 6 (Pdcd6) | Cyclin I |
| Cyclin-dependent kinase 5 (cdk5) | Baculoviral IAP repeat-containing 5 (survivin) | Cysteine-rich protein, nucleolar (Hsa6591) | |
| Cyclin-dependent kinase 9 (Cdk9) | B-cell translocation gene 3 (Btg3) | Polo-like kinase (Plk) | |
| Inhibin beta E (Inhbe) | Caspase-11 | Rcl, c-myc responsive | |
| Leukemia inhibitory factor receptor (Lifr) | Caspase-3 | Circadian oscillary protein (Scop) | |
| Proliferating cell nuclear antigen (PCNA) | Cdc20 | ||
| Prolactin-like protein A (Prlpa) | Cell division cycle 2 homolog A (Cdc2a) | ||
| Prothymosin alpha (Ptma) | Cell division cycle 6 homolog (Cdc6) | ||
| TOB3 | CDC28 protein kinase 1 (Cks 1) | ||
| Cytochrome c-1 (Cyc 1) | |||
| Cyclin A2 | |||
| Cyclin B2 | |||
| Geminin (Gmnn) | |||
| MAD2 (mitotic arrest deficient)-like 1 (mad211) | |||
| Antigen identified by monoclonal antibody Ki 67 | |||
| Protein regulator of cytokinesis 1-like (Prc 1) | |||
| Neural stem cell-derived neuronal survival (Sdnsf) | |||
| Serine (or cysteine) proteinase inhibitor (Serpinb6) | |||
| Cd27 binding protein (Hindu God of destruction, Siva) | |||
| DNA/RNA metabolism | |||
| Apoptotic chromatin condensation ind in nucleus (Acinus) | Brain abundant, membrane-attached signal protein 1 (Basp 1) | Eukaryotic translation initiation factor 4 gamma (elF4g1) | BAF53A, chromatin remodeling |
| Absent, small, or homeotic discs 1 (Ash 1) | Eukaryotic translation elongation factor 1 delta (Eefld) | Histone family member H2B/S | Centromere protein A (Cenpa) |
| D-E-A-D box polypeptide 6 (Dbp6) | Eukaryotic translation initiation factor 3, subunit 7 (elF3s7) | H2B histone family, member H2BFS | elF-3s8 |
| Excision repair cross-comp repair deficiency (Ercc2) | ELL-related RNA polymerase II (E112) | H4 histone family, member H4FG | Glycyl-tRNA synthetase (Gars) |
| General control of amino acid synthesis-like 2 (Gen512) | High-mobility group box 2 nuclear protein (Hmgb2) | Polymerase (DNA directed), mu (Polm) | Histone H1x (H1fx) |
| General transcription factor III A (Gtf3a) | High-mobility group nucleosomal binding domain 2 (Hmgn2) | RNA binding motif, ss interacting protein (MSSP-1, Rbms 1) | IGF-II mRNA-binding protein 3 (Koc1) |
| H3 histone, family 3A (H3f3a) | Hn ribonucleoproteins methyltransferase-like 2 (Hhmr112) | Ribosomal protein S11 | Mitochondrial ribosomal protein S27 (Mrps27) |
| High mobility group nucleosomal binding domain 2 (Hmgn2) | Eukaryotic translation initiation factor 1A (IFly) | 40S ribosomal protein SA (Rsp4) | 8-oxoguanine DNA glycosylase (Oggl) |
| Mini chromosome maintenance-deficient 4 homolog (Mcmd4) | Mini chromosome maintenance deficient (Mcmd) | Splicing factor 3a, subunit 2 (Sf3a2) | DNA polymerase delta small subunit (Polo2) |
| Polymerase (DNA directed) alpha 2 (Pola2) | MORF-related gene X (mrgx) | SWI/SNF related regulator of chromatin (Smarca4) | RNA polymerase II, polypeptide J (Polr2j) |
| Polymerase (DNA directed) mu (Polm) | Mitochondrial ribosomal protein L30 (Mrpl30) | SWI/SNF related regulator of chromatin (Smarcb 1) | Replication protein A3 (Rpa3) |
| RAD51-associated protein 1 (Rad51 ap 1) | Polymerase (DNA directed), alpha 2 (Pola2) | Transcription termination factor, RNA polymerase I (Ttf1) | Seryl-tRNA synthetase (Sars) |
| Ribosomal protein L32 | RNA binding motif protein 10 (Rbm 10) | Zinc-finger helicase (hZFH) | Small nuclear ribonucleoprotein polypeptides B and B1 (Snrpb) |
| Ribosomal protein L5 | RNA binding motif protein 3 (Rbm3) | Zinc finger protein 161 (Znf161) | Structure-specific recognition protein 1 (Ssrp 1) |
| Ribosomal protein L7 | RNA binding motif, ss interacting protein (MSSP-1, Rbms 1) | Zinc finger protein 220 (Znf220) | ATP-dependent mitochondrial RNA helicase (SUV3, Sars) |
| Ribosomal protein S26 | Ribosomal protein L22 | Transcription elongation factor A (SII, Tceal) | |
| Ribosomal protein S4, X-linked (Rps4x) | Ribosomal protein S6 kinase polypeptide 1 (Rps6ka1) | Topoisomerase (DNA) II alpha (Top2a) | |
| Suppressor of Ty 4 homolog (Spt4h) | Ribosome binding protein 1 (Rrbp 1) | UMP synthase (Umps) | |
| DNA/RNA metabolism (continued) | |||
| Xlr-related, meiosis regulated (Xmr) | Ribonucleotide reductase M1 (Rrm1) | Tyrosyl-tRNA synthetase (Yars) | |
| Tyrosyl-tRNA synthetase (Yars) | Ribonucleotide reductase M2 subunit (Rrm2) | Zinc finger protein 9 (Znf9) | |
| Zinc finger protein 125, (ZT2, Zfp 125) | Topoisomerase (DNA) II alpha (Top2a) | Eukaryotic translation termination factor 1 (Etf1) | |
| Zinc finger protein, multitype (FOG Friend of GATA, Zfpm1) | |||
| Inflammation/immunity | |||
| Allograft inflammatory factor 1 (lbal, Aif1) | Lipocortin 1, annexin A1 (Anxa1) | Ig alpha chain C region (Alc) | |
| Complement component 9 (C9) | B-cell-receptor gene (Bcr) | CD86 antigen (CD28 antigen ligand 2, B7-2) | |
| Calumenin (Calu) | Complement Clq B chain (Clqb) | C-type lectin, superfamily member 2 (Clecsf2) | |
| CD84 antigen | Complement component 1, q subcomponent, c (Clqc) | HCGII-7 hemochromatosis candidate genes | |
| Fibroblast growth factor 1 (Fgf1) | Calumenin, secretory pathway (Calu) | Regulatory factor X, 2 (Rfx2) | |
| Fibroblast growth factor 5 (Fgf5) | CD68 antigen | ||
| Interferon activated gene 204 (lfi204) | CD7 antigen | ||
| Germ line immunoglobulin V(H)II gene H8 | CD9 antigen | ||
| Interferon gamma-inducing factor binding protein (lgifbp) | Cathelin-like protein (CLP, CRAMP, Cnlp) | ||
| Immunoglobuling J chain | Cytokine receptor-like molecule (EB13), EBV-ind gene 3 | ||
| Immunoglobulin kappa chain variable 20 (V20 family) | Endoglin (Eng) | ||
| Interleukin-13 receptor, alpha 2 (IL-13a2) | Ficolin A (Fena) | ||
| Interleukin-5 (IL-5) | Histocompatibility 13 (H13) | ||
| Immunity-associated protein (Imap) | Histocompatibility 47 (H47) | ||
| Lymphocyte-activation gene 3 (Lag 3) | H-2 class I histocompatibility antigen (HA1D) | ||
| Lymphocyte antigen 6 complex, locus D (Ly-6d) | Ig heavy chain V region (MPC 11, HV01) | ||
| Reg factor X-ass ankyrin-containing protein (Rfxank) | Single chain antibody scFv (scFvCPSQ) | ||
| TNF receptor superfamily, member 8 (Tnfrsf8) | mRNA (IB5) for IgA V-D-J-heavy chain | ||
| Immunoglobulin heavy chain V region mRNA | |||
| Clone WS2a43 mutated immunoglobulin heavy chain | |||
| Immunoglobulin heavy chain 8 (heavy chain of IgG3) | |||
| Ig active joining chain (J chain) of the b allele | |||
| Immunoglobulin kappa light chain variable region | |||
| Immunoglobulin variable gene V kappa | |||
| Immunoglobulin light chain V region | |||
| Immunoglobulin light chain IgG | |||
| Anti-DNA immunoglobulin light chain IgG | |||
| Extrachromosomal DNA for V kappa and J k coding joint | |||
| Ig rearranged truncated mu-chain | |||
| IFN-stimulated protein, 20 kDa (Isg207) | |||
| Integral membrane protein 3 (Itm3) | |||
| Immunoglobulin J chain | |||
| Lymphocyte antigen 6 complex, locus C (Ly-6c) | |||
| Mannose receptor, C type 1 (Mrc1) | |||
| Intracellular ca-binding prot (MRP 14, calgranulin B, s100a9) | |||
| Secretory leukoprotease inhibitor gene (Slpi) | |||
| TGF beta 1 induced transcript 4 (Tgfbli4) | |||
| TNF receptor superfamily, member 17 (Tnfrsf17) | |||
| Vascular cell adhesion molecule 1 (Vcam1) | |||
| Signaling | |||
| Adrenergic receptor, beta 3 (Adrb3) | rhoB gene, ras homolog (Arhb) | Ras homolog gene family, member G (rho G Arhg) | Cornichon-like (Cnil) |
| Cadherin EGF LAG 7-pass G-type rec 2 (flamingo 1, Celsr2) | Arsenate resistance protein 2 (Acr2, Ars2) | Rho GDP dissociation inhibitor (GDI) alpha (Arhgdia) | Dual-specificity tyr-phosphorylation reg kinase 1A (Dyrk 1a) |
| Calcium and integrin binding 1 (calmyrin, KIP, Cib 1) | GP1-anchored membrane protein 1 (Gpiap 1) | GTP binding protein overexpressed in skeletal muscle (Gem) | FK506 binding protein 2 (Fkbp2) |
| Cytokine inducible SH2-containing protein (SOCS-1, Cis) | Gene trap locus 3, Delta-like Dlk1 (Gtl3) | 5-hydroxytryptamine (serotonin) receptor 1E (Htr1e) | Guanylate cyclase activator (Guca1b) |
| Creatine kinase, mitochondrial 1 (Ckmt 1) | Potentially oncogenic Ras (Ki-Ras) | Inositol 1,4,5-triphosphate receptor, type 1 (ltpr 1) | Hyaluronan-mediated motility receptor (RHAMM CD168, Hmmr) |
| Tyrosine protein kinase (Csk) | Kit oncogene | Mitogen-activated protein kinase kinase 2 (Map2k2) | Mitogen-act protein kinase kinase kinase kinase 1 (Map4k1) |
| Casein kinase 1, delta (Csnk 1d) | Membrane-spanning 4-domains (Ms4a6b) | Pecanex-like 3 (Penxl3) | Adaptor protein p 150, P13-kinase regulatory subunit 4 (Pik3r4) |
| Delta-like 1 (Dll 1) | Phosphatidylinositol-4-phosphate 5-kinase (Pip5k2a) | 3-phosphoinositide-dependent protein kinase-1 (Pdpk 1) | Protein phosphatase 1G (formerly 2C) (PPM1G) |
| Ectodermal-neural cortex 1 (Enc1) | Protein tyrosine phosphatase, nonreceptor type 8 (Ptpn8) | Protein phosphatase 3 (formerly 2B)(calcineurin A alpha) | Protein phosphatase 2 (formerly 2A)(Ppp2r2a) |
| FK506 binding protein 4 (Fkbp4) | Protein tyr pptase, nonreceptor type (SHPS, BIT, Ptpns 1) | RaP2 interacting protein 8, small GTPase int prot (Rpip8) | |
| Fyn-related kinase (Frk) | Sell (suppressor of lin-12) 1 homolog (Sel1h) | Sac domain-containing inositol phosphatase 3 (Sac3) | |
| Frizzled homolog 2 (Fzd2) | Signal-transducing adaptor molecule 1 (Stam 1) | Tyrosine kinase 2 (Tyk2) | |
| Frizzled homolog 8 (Fzd8) | WW domain binding protein 2 (Wbp2) | Unc-51-like kinase 1 (Ulk 1) | |
| Ras GTPase activating protein binding protein 1 (G3BP) | Zeta-chain (TCR)-associated protein kinase (Zap-70) | ||
| Growth hormone-inducible transmembrane protein (Ghitm) | |||
| Protein phosphatase 3, catalytic subunit (Ppp3ca) | |||
| Protein tyrosine phosphatase, receptor type (Ftp-1, Ptprl) | |||
| GTP binding nuclear protein (Ran) | |||
| Wingless related MMTV integration site 10b (Wnt10b) | |||
| Wingless-related MMTV integration site 6 (Wnt6) | |||
| Transcription factors | |||
| BarH-like homeobox 1 (Barx1) | Carbon catabolite repression 4 homolog (Ccr4) | Bromodomain-containing 3 (Brd3) | Leucine-zipper protein, repressor of cAMP, MAPK (Atf5) |
| Distal-less homeobox 2 (Dlx2) | CCAAT/enhancer binding protein (C/EBP) | BTB (POZ) domain-containing 3 (Btbd3) | Cellular repressor of E1A-stimulated genes (Creg) |
| GLI-Kruppel family member (Gli1) | Cellular repressor of E1A-stimulated genes (Creg) | Bithorax Bx1 homeobox (Bx1) | Alternatively spliced cut-like 1 (Cutl1) |
| H6 homeobox 3 repressor (Hmx3) | dbpA homologue, cold shock domain protein A (Csda6) | CCR4-NOT transcription complex, subunit 8 (Cnot8) | Forkhead protein (FKHRLI, Fox03a) |
| LIM homeobox protein 1 (Lhx1) | Transcription factor (Dp 1) | NFk light polypeptide enhancer in B cells inhibitor (nfkbia) | |
| Similar to zinc finger protein pMLZ-4 (Mlz-4) | ets variant gene 6 (TEL, Etv6) | PR domain-containing 2, with ZNF domain (Prdm2) | |
| Myogenin (Myog) | Ewing sarcoma homolog (Ews) | Sirtuin silent mating type information reg 2 homolog 6 (Sirt6) | |
| Y-box binding protein (oxyR) | Enhancer of zeste homolog 2 (Ezh2) | SP140 nuclear body protein | |
| Paired box gene 3 (Pax3) | HIV type 1 enhancer binding protein 1 (Hivep 1) | ||
| Norepinephrine transporter (SLC6A5) | Inhibitor protein (Id2) | ||
| T-cell factor-1 (Tcf-1) | Makorin, ring finger protein, (Mkm1) | ||
| Transcription factor AP-2 beta (Tcfap2b) | T-cell acute leukemia 1 (Tal1) | ||
| Transcription factor 7 (Tcf7) | |||
| X-box binding protein 1 (Xbp1) | |||
| Tumor-associated | |||
| ElaC homolog 2 (Elac2) | Arginine-rich, mutated in early stage tumors (Armet) | HLA-B-associated transcript 3 (Bat3) | |
| Leukemia-associated gene (Pr22, Lag) | Ecotropic viral integration site 2 (Evi2) | Prostate tumor overexpressed gene 1 (Ptov 1) | |
| Neoplastic progression 2 (Npn2) | Immunoglobulin superfamily, member 4 (TSLC1, Igsf4) | ||
| Gene overexpressed in astrocytoma (Goa, Oea) | Leukemia-associated gene (Lag) | ||
| Proviral integration site 1 (Pim 1) | Expressed in nonmetastatic cells 3 (Nme3) | ||
| T-cell leukemia/lymphoma 1B (Tcl 1 bl) | Protein-serine/threonine kinase (Pim2) | ||
| Secreted acidic cys-rich glycoprotein/osteonectin (Sparc) | |||
| Ubiquitination | |||
| Proteasome (prosome, macropain) 26S subunit (psmd3) | Proteasome (prosome, macropain) subunit (Psma4) | F-box and leucine-rich repeat protein 7 (Fb17) | Proteasome (prosome, macropain) 26S subunit (Psmd8) |
| WW domain-containing protein 4 (Wwp2) | Proteasome (prosome, macropain) 26S subunit (psmc2) | Proteasome (prosome, macropain) subunit (Psmb9) | Ubiquitin-conjugating enzyme E2C (Ube2c) |
| Proteasome (prosome, macropain) 26S subunit (Psmd11) | Ubiquitin-conjugating enzyme E21 (UBC9, Ube21) | ||
| Ubiquitin fusion degradation 1-like (Ufd 11) | Ubiquitin-specific protease 22 (Usp22) |
At least 2 separate, identical experiments comparing gene transcription in LMP2A-positive versus LMP2A-negative cells were performed for each cell type. Statistical analyses of the arrays were performed as described in “Materials and methods.” Genes with probability values of less than .01 and differential ratios of greater than 1.1 in LMP2A-positive cells compared with LMP2A-negative cells are listed.