Table 1. Equilibrium dissociation... | American Society of Hematology

Table 1.

Equilibrium dissociation constants for the binding of the physiological pentasaccharide by antithrombin

Antithrombin	Ionic strength	K_d, nM	Fmax, %
Plasma α	0.15	48 ± 1	40 ± 2
	0.3	474 ± 8	40 ± 1
Plasma β ^*	0.3	36 ± 3	NR
S137A	0.3	37 ± 2	41 ± 1
A384S	0.3	35 ± 1	40 ± 1
N135Q ^*	0.3	20 ± 2	NR
N135A †	0.3	24 ± 2	NR

Antithrombin	Ionic strength	K_d, nM	Fmax, %
Plasma α	0.15	48 ± 1	40 ± 2
	0.3	474 ± 8	40 ± 1
Plasma β ^*	0.3	36 ± 3	NR
S137A	0.3	37 ± 2	41 ± 1
A384S	0.3	35 ± 1	40 ± 1
N135Q ^*	0.3	20 ± 2	NR
N135A †	0.3	24 ± 2	NR

NR indicates not reported; Fmax, maximum intrinsic fluorescence enhancement.

From Turko et al 1993.⁴³

From Turk et al 1997.⁴⁴