Differential gene expression in CLL cells treated with Bryostatin 1 or IFNγ
. | Number of genes differentially expressed . | . | . | ||
|---|---|---|---|---|---|
| Treatment . | Up-regulated . | Down-regulated . | Total . | ||
| Bryostatin 1, compared with untreated | 839 | 450 | 1289 | ||
| IFNγ, compared with untreated | 115 | 139 | 254 | ||
| Overlap between Bryostatin 1 and IFNγ | 39 | 39 | 78 | ||
. | Number of genes differentially expressed . | . | . | ||
|---|---|---|---|---|---|
| Treatment . | Up-regulated . | Down-regulated . | Total . | ||
| Bryostatin 1, compared with untreated | 839 | 450 | 1289 | ||
| IFNγ, compared with untreated | 115 | 139 | 254 | ||
| Overlap between Bryostatin 1 and IFNγ | 39 | 39 | 78 | ||
Total RNA was isolated from CLL cells stimulated for 3 hours with 10 nM Bryostatin 1 or 10 U/mL IFNγ. Differential gene expression was analyzed using oligonucleotide arrays (Affymetrix, HG-U133A).