Genes with lower levels of expression in MLBCL*
Gene class and specific genes . | Fold change† . |
|---|---|
| B-cell receptor components and signaling cascade | |
| IgMठ| 5.1 |
| B-cell lymphocyte kinase (BLK)‡ | 2.7 |
| SH3 domain-binding protein (SAB) (BTK-associated binding protein) | 2.0 |
| B-cell linker protein (BLNK)‡ | 1.5 |
| PKCβI‡ | 2.0 |
| NFATc‡ | 2.0 |
| AKT-1 | 1.5 |
| CD22‡ | 2.6 |
| Transcription factors | |
| Spi-B‡ | 1.6 |
| Ikaros | 1.5 |
| FOXP1 | 2.0 |
| Class II MHC componentsठ| |
| DO⇠| 1.9 |
| DQβ | 2.0 |
| DMα | 1.5 |
| Germinal center and other B-cell markers | |
| CD10 | 3.1 |
| SPAP1 (SH2 domain-containing phosphatase anchor protein, IRTA 4) | 2.4 |
| Protein tyrosine phosphatase receptor type C (PTPRCAP) | 1.4 |
| TNF family members | |
| Transmembrane activator and CAML interactor (TAC1) (TNFRSF13B) | 1.5 |
| CD27 (TNFRSF7) | 1.7 |
| TRAF5‡ | 1.5 |
| Cytokines | |
| Interleukin-16‡ | 1.4 |
Gene class and specific genes . | Fold change† . |
|---|---|
| B-cell receptor components and signaling cascade | |
| IgMठ| 5.1 |
| B-cell lymphocyte kinase (BLK)‡ | 2.7 |
| SH3 domain-binding protein (SAB) (BTK-associated binding protein) | 2.0 |
| B-cell linker protein (BLNK)‡ | 1.5 |
| PKCβI‡ | 2.0 |
| NFATc‡ | 2.0 |
| AKT-1 | 1.5 |
| CD22‡ | 2.6 |
| Transcription factors | |
| Spi-B‡ | 1.6 |
| Ikaros | 1.5 |
| FOXP1 | 2.0 |
| Class II MHC componentsठ| |
| DO⇠| 1.9 |
| DQβ | 2.0 |
| DMα | 1.5 |
| Germinal center and other B-cell markers | |
| CD10 | 3.1 |
| SPAP1 (SH2 domain-containing phosphatase anchor protein, IRTA 4) | 2.4 |
| Protein tyrosine phosphatase receptor type C (PTPRCAP) | 1.4 |
| TNF family members | |
| Transmembrane activator and CAML interactor (TAC1) (TNFRSF13B) | 1.5 |
| CD27 (TNFRSF7) | 1.7 |
| TRAF5‡ | 1.5 |
| Cytokines | |
| Interleukin-16‡ | 1.4 |
Gene list derived from the top 400 genes with lower levels of expression in MLBCL. All genes significant at P < .01
Fold change compared with DLBCL
Previously identified as having reduced expression in Hodgkin Reed-Sternberg cells: IgM, CD22, BLK, PKCβI/II, BLNK, NFATc, Spi-B, class II DOβ, TRAF5, and IL-16.17
Previously identified as having reduced expression in MLBCL: Ig2 and MHC class II.41