Genes with higher levels of expression in MLBCL*
Gene class and specific genes . | Fold change† . |
|---|---|
| Cytokines and cytokine pathways | |
| IL-13Rα1‡ | 1.9 |
| JAK2‡ | 2.0 |
| STAT1‡ | 1.7 |
| Interleukin-4—induced gene 1 (FIG1)§ | 1.7 |
| NF—IL-3‡ | 2.0 |
| γIFN-inducible protein 10 (IP10/CXCR3 ligand)‡ | 2.0 |
| γIFN-inducible protein 30 (IFI30/GILT) | 1.6 |
| IFN-induced protein 35 | 1.5 |
| RANTES (CCL5)‡ | 1.9 |
| Chemokine receptor 1 (CCR1) | 1.5 |
| RON (macrophage-stimulating 1 receptor/c-met—related TK) | 1.7 |
| Interleukin-15 | 1.7 |
| TNF family members and induced proteins | |
| OX40 ligand (TNFSF4)‡ | 2.0 |
| FAS ligand receptor/CD95 (TNFRSF6)ठ| 1.7 |
| Herpes virus entry mediator (HVEM, TNFRSF14) | 1.5 |
| TRAF1‡ | 1.8 |
| TNF-α—induced protein 3 (A20)‡ | 1.6 |
| TNF-α—induced protein 6 | 2.3 |
| Costimulatory molecules and inflammatory mediators | |
| SLAM | 1.7 |
| CD80 (B7.1)‡ | 1.4 |
| CD86 (B7.2)‡ | 1.4 |
| Cyclooxygenase 1 | 1.9 |
| Prostaglandin receptor (IP) | 2.6 |
| Cell adhesion molecules/extracellular matrix components | |
| Fibroblast growth factor receptor-1 | 1.4 |
| CD58 (lymphocyte-function associated antigen 3)ठ| 1.5 |
| Integrin α M (CD11b) | 1.8 |
| Fibronectin | 3.0 |
| Fibroblast activation protein α (seprase) | 2.0 |
| Decorin | 2.0 |
| Collagen type III α 1 | 2.1 |
| Collagen type IV α 1 | 2.3 |
| Collagen type IV α 2 | 1.6 |
| Matrix metalloproteinase 14 | 2.0 |
| Tissue inhibitor of metallo-proteinase 1‡ | 1.9 |
| Other | |
| MAL§ | 2.8 |
| SNFT (Jun dimerization protein) | 2.8 |
| Adenosine deaminase | 1.9 |
Gene class and specific genes . | Fold change† . |
|---|---|
| Cytokines and cytokine pathways | |
| IL-13Rα1‡ | 1.9 |
| JAK2‡ | 2.0 |
| STAT1‡ | 1.7 |
| Interleukin-4—induced gene 1 (FIG1)§ | 1.7 |
| NF—IL-3‡ | 2.0 |
| γIFN-inducible protein 10 (IP10/CXCR3 ligand)‡ | 2.0 |
| γIFN-inducible protein 30 (IFI30/GILT) | 1.6 |
| IFN-induced protein 35 | 1.5 |
| RANTES (CCL5)‡ | 1.9 |
| Chemokine receptor 1 (CCR1) | 1.5 |
| RON (macrophage-stimulating 1 receptor/c-met—related TK) | 1.7 |
| Interleukin-15 | 1.7 |
| TNF family members and induced proteins | |
| OX40 ligand (TNFSF4)‡ | 2.0 |
| FAS ligand receptor/CD95 (TNFRSF6)ठ| 1.7 |
| Herpes virus entry mediator (HVEM, TNFRSF14) | 1.5 |
| TRAF1‡ | 1.8 |
| TNF-α—induced protein 3 (A20)‡ | 1.6 |
| TNF-α—induced protein 6 | 2.3 |
| Costimulatory molecules and inflammatory mediators | |
| SLAM | 1.7 |
| CD80 (B7.1)‡ | 1.4 |
| CD86 (B7.2)‡ | 1.4 |
| Cyclooxygenase 1 | 1.9 |
| Prostaglandin receptor (IP) | 2.6 |
| Cell adhesion molecules/extracellular matrix components | |
| Fibroblast growth factor receptor-1 | 1.4 |
| CD58 (lymphocyte-function associated antigen 3)ठ| 1.5 |
| Integrin α M (CD11b) | 1.8 |
| Fibronectin | 3.0 |
| Fibroblast activation protein α (seprase) | 2.0 |
| Decorin | 2.0 |
| Collagen type III α 1 | 2.1 |
| Collagen type IV α 1 | 2.3 |
| Collagen type IV α 2 | 1.6 |
| Matrix metalloproteinase 14 | 2.0 |
| Tissue inhibitor of metallo-proteinase 1‡ | 1.9 |
| Other | |
| MAL§ | 2.8 |
| SNFT (Jun dimerization protein) | 2.8 |
| Adenosine deaminase | 1.9 |
Gene list derived from the top 400 genes with higher levels of expression in MLBCL. All genes significant at P < .01
Fold change compared with DLBCL
Previously identified in Hodgkin Reed-Sternberg cells: IL-13R,23,24 JAK2,25,26 STAT1,27 NF—IL-3,28 IP10,29 RANTES,29 OX40L,30 CD95,30 TRAF1,31,32 A20,33 CD80,34 CD86,35 CD58,36 and TIMP1.37
Previously identified in MLBCL: FIG1,21 FAS/Apo1/CD95,38 MAL,8,39 and CD58.22,36