Gains and parental origin of duplicated chromosomes in 10 hyperdiploid childhood pre-B ALL
. | Chromosome . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patient . | 2 . | 4 . | 5 . | 6 . | 7 . | 8 . | 9 . | 10 . | 11 . | 12 . | 13 . | 14 . | 15 . | 17 . | 18 . | 21 . | 22 . | X . | |||||||||||||||||
1 | NI | M | D | P | D | D | D | M | D | NI | D | M | D | M | P | T | D | P/pat | |||||||||||||||||
2 | D | D | D | M | D | D | D | P | D | NI | D | M | NI | M | D/mut | T | D | — | |||||||||||||||||
3 | D | P/mut | D | P | D | D | D | D | D | D | D | P | D | M | M | T | D | D/NI | |||||||||||||||||
4 | D | M | D | P | D | P | D | P | D | D | D | M | D | P | M | T | D | P/mat | |||||||||||||||||
5 | LOH | M | D | M | D | D/mut | D | P | D | LOH | NI | M | D | M | P | T | D | — | |||||||||||||||||
6 | NI | M | D | P | NI | D | P | P | D | NI | D | D | D | M | D | T | D | — | |||||||||||||||||
7 | NI | P | D | D | NI | D | D | D | D | D | D | M | NI | P | P | M | D | D/mat | |||||||||||||||||
8 | D | P | D | M | D | P | LOH/d | D | D | D | D | M | D | P | P | P | D | — | |||||||||||||||||
9 | NI | M | D | M | D | P | M | M | LOH | D | D | M | D | P | P | T | D | — | |||||||||||||||||
10 | NI | P | D | M | D | P | LOH | P | D | D | D | D | MSI | M | D | T | D | — | |||||||||||||||||
P | — | 1 | — | 1 | — | .125 | — | .453 | — | — | — | .0703 | — | .754 | .453 | — | — | .500 |
. | Chromosome . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patient . | 2 . | 4 . | 5 . | 6 . | 7 . | 8 . | 9 . | 10 . | 11 . | 12 . | 13 . | 14 . | 15 . | 17 . | 18 . | 21 . | 22 . | X . | |||||||||||||||||
1 | NI | M | D | P | D | D | D | M | D | NI | D | M | D | M | P | T | D | P/pat | |||||||||||||||||
2 | D | D | D | M | D | D | D | P | D | NI | D | M | NI | M | D/mut | T | D | — | |||||||||||||||||
3 | D | P/mut | D | P | D | D | D | D | D | D | D | P | D | M | M | T | D | D/NI | |||||||||||||||||
4 | D | M | D | P | D | P | D | P | D | D | D | M | D | P | M | T | D | P/mat | |||||||||||||||||
5 | LOH | M | D | M | D | D/mut | D | P | D | LOH | NI | M | D | M | P | T | D | — | |||||||||||||||||
6 | NI | M | D | P | NI | D | P | P | D | NI | D | D | D | M | D | T | D | — | |||||||||||||||||
7 | NI | P | D | D | NI | D | D | D | D | D | D | M | NI | P | P | M | D | D/mat | |||||||||||||||||
8 | D | P | D | M | D | P | LOH/d | D | D | D | D | M | D | P | P | P | D | — | |||||||||||||||||
9 | NI | M | D | M | D | P | M | M | LOH | D | D | M | D | P | P | T | D | — | |||||||||||||||||
10 | NI | P | D | M | D | P | LOH | P | D | D | D | D | MSI | M | D | T | D | — | |||||||||||||||||
P | — | 1 | — | 1 | — | .125 | — | .453 | — | — | — | .0703 | — | .754 | .453 | — | — | .500 |
NI indicates not informative; M, maternal chromosome duplicated; D, disomic; P, paternal chromosome duplicated; T, tetrasomic; mut, mutation (difference in the length of the microsatellite repeat during transmission from parent to child); pat, paternal X active; mat, maternal X active; d, homozygous deletion; MSI, microsatellite instability; and —, not done.