Genomic aberrations in MCL overall and according to VH mutation status
Aberration . | Patients with aberrations (%) . | VH-mutated (%) . | VH-unmutated (%) . | Odds ratios VH-mutated/VH-unmutated (95% confidence interval) . |
|---|---|---|---|---|
| 3q trisomy | 36 of 86 (41.9) | 6 of 24 (25) | 30 of 62 (48.4) | 0.36 (0.12-1.02) |
| 8q trisomy | 19 of 87 (21.8) | 2 of 25 (8) | 17 of 62 (27.4) | 0.23 (0.05-1.08) |
| 12q trisomy | 14 of 86 (16.3) | 7 of 24 (29.2) | 7 of 62 (11.3) | 3.24 (0.99-10.5) |
| 6q deletion | 15 of 87 (17.2) | 6 of 25 (24) | 9 of 62 (14.5) | 1.86 (0.58-5.92) |
| 11q deletion | 35 of 87 (40.2) | 11 of 25 (44) | 24 of 62 (38.7) | 1.24 (0.49-3.19) |
| 13q deletion | 43 of 87 (49.4) | 10 of 25 (40) | 33 of 62 (53.2) | 0.59 (0.23-1.50) |
| 17p deletion | 18 of 86 (18) | 7 of 25 (28) | 11 of 61 (18) | 1.77 (0.59-5.26) |
| Tetraploidy | 12 of 87 (13.8) | 1 of 25 (4) | 11 of 62 (17.7) | 0.19 (0.02-1.58) |
| Complex* | 29 of 86 (33.7) | 5 of 24 (20.8) | 24 of 62 (38.7) | 0.42 (0.14-1.26) |
| No aberration | 13 of 86 (13) | 3 of 24 (12.5) | 10 of 62 (16.1) | 0.74 (0.19-2.97) |
Aberration . | Patients with aberrations (%) . | VH-mutated (%) . | VH-unmutated (%) . | Odds ratios VH-mutated/VH-unmutated (95% confidence interval) . |
|---|---|---|---|---|
| 3q trisomy | 36 of 86 (41.9) | 6 of 24 (25) | 30 of 62 (48.4) | 0.36 (0.12-1.02) |
| 8q trisomy | 19 of 87 (21.8) | 2 of 25 (8) | 17 of 62 (27.4) | 0.23 (0.05-1.08) |
| 12q trisomy | 14 of 86 (16.3) | 7 of 24 (29.2) | 7 of 62 (11.3) | 3.24 (0.99-10.5) |
| 6q deletion | 15 of 87 (17.2) | 6 of 25 (24) | 9 of 62 (14.5) | 1.86 (0.58-5.92) |
| 11q deletion | 35 of 87 (40.2) | 11 of 25 (44) | 24 of 62 (38.7) | 1.24 (0.49-3.19) |
| 13q deletion | 43 of 87 (49.4) | 10 of 25 (40) | 33 of 62 (53.2) | 0.59 (0.23-1.50) |
| 17p deletion | 18 of 86 (18) | 7 of 25 (28) | 11 of 61 (18) | 1.77 (0.59-5.26) |
| Tetraploidy | 12 of 87 (13.8) | 1 of 25 (4) | 11 of 62 (17.7) | 0.19 (0.02-1.58) |
| Complex* | 29 of 86 (33.7) | 5 of 24 (20.8) | 24 of 62 (38.7) | 0.42 (0.14-1.26) |
| No aberration | 13 of 86 (13) | 3 of 24 (12.5) | 10 of 62 (16.1) | 0.74 (0.19-2.97) |
Three or more aberrations.