Table 2.

Frequency of VH,D, and JH genes*and VDJ structure in 148 rearrangements of 141 MCL patients: incidence and distribution according to VH mutation status

Overall
VH mutated
VH unmutated
Differential distribution, adjusted P†
VH gene, n  148   42   106   
    V4-34  23 (15.5)   2 (4.8)   21 (19.8)   .05  
    V3-21  18 (12.1)   0 (0)   18 (17)   .008  
    V1-08  15 (10.1)   3 (7.1)   12 (11.3)   .56  
    V3-23  11 (7.4)   7 (16.7)   4 (3.8)   .04  
    V4-59  10 (6.8)   9 (21.4)   1 (0.9)   .005  
    Other   71 (48)   21 (50)   50 (47.2)   —  
JH gene, n  145   42   103   
    JH4b  62 (42.8)   26 (61.9)   36 (35)   .02  
    JH5b  29 (20)   6 (14.3)   23 (22.3)   .72  
    JH6b  22 (15.2)   6 (14.3)   16 (15.5)   1.0  
    JH6c  14 (9.7)   2 (4.8)   12 (11.7)   .35  
    Other   18 (12.4)   2 (4.8)   16 (15.5)   —  
D gene, n  94   18   76   
    D2-2  16 (17)   3 (16.7)   13 (17.1)   1.0  
    D3-3  14 (14.9)   1 (5.6)   13 (17.1)   .58  
    Other   64 (68.1)   14 (77.8)   50 (65.8)   —  
CDR3, n  148   42   106   
    Median length in      
    codons      
    [quartiles]
 		 13 [10, 17]
 		 11 [9, 14]
 		 15 [11, 18]
 		 < .001‡
 
Overall
VH mutated
VH unmutated
Differential distribution, adjusted P†
VH gene, n  148   42   106   
    V4-34  23 (15.5)   2 (4.8)   21 (19.8)   .05  
    V3-21  18 (12.1)   0 (0)   18 (17)   .008  
    V1-08  15 (10.1)   3 (7.1)   12 (11.3)   .56  
    V3-23  11 (7.4)   7 (16.7)   4 (3.8)   .04  
    V4-59  10 (6.8)   9 (21.4)   1 (0.9)   .005  
    Other   71 (48)   21 (50)   50 (47.2)   —  
JH gene, n  145   42   103   
    JH4b  62 (42.8)   26 (61.9)   36 (35)   .02  
    JH5b  29 (20)   6 (14.3)   23 (22.3)   .72  
    JH6b  22 (15.2)   6 (14.3)   16 (15.5)   1.0  
    JH6c  14 (9.7)   2 (4.8)   12 (11.7)   .35  
    Other   18 (12.4)   2 (4.8)   16 (15.5)   —  
D gene, n  94   18   76   
    D2-2  16 (17)   3 (16.7)   13 (17.1)   1.0  
    D3-3  14 (14.9)   1 (5.6)   13 (17.1)   .58  
    Other   64 (68.1)   14 (77.8)   50 (65.8)   —  
CDR3, n  148   42   106   
    Median length in      
    codons      
    [quartiles]
 		 13 [10, 17]
 		 11 [9, 14]
 		 15 [11, 18]
 		 < .001‡
 

All values in parentheses are percentages.—indicates not done.

*

Gene frequency in 10 or more patients.

†

To account for multiple testing, family/genewise P values were adjusted according to Holm.43 

‡

Estimated difference, 3 codons (95% confidence limits, 2-4 codons).

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