Table 6. Univariate analysis of risk... | American Society of Hematology

Table 6.

Univariate analysis of risk factors for mortality after IPS

Variables	Total no. patients	Mortality after IPS, no. patients (%)	P
Mechanical ventilation			.001‡
Not initiated	31	12 (39)
Initiated	50	48 (96)
Creatinine concentration at IPS*			.001‡
Less than 2 mg/dL	52	32 (62)
2 mg/dL or more	29	28 (97)
Total bilirubin concentration at IPS*			.037
Less than 4 mg/dL	49	32 (65)
4 mg/dL or more	32	28 (87)
Vasopressor use at IPS*			.017
No	68	47 (69)
Yes	13	13 (100)
Donor			.023
HLA-matched related	37	32 (86)
HLA-mismatched/unrelated	44	28 (64)
Corticosteroids for IPS†			.015
None	10	10 (100)
2 mg/kg/d or less	28	16 (57)
4 mg/kg/d or more	43	34 (79)

Variables	Total no. patients	Mortality after IPS, no. patients (%)	P
Mechanical ventilation			.001‡
Not initiated	31	12 (39)
Initiated	50	48 (96)
Creatinine concentration at IPS*			.001‡
Less than 2 mg/dL	52	32 (62)
2 mg/dL or more	29	28 (97)
Total bilirubin concentration at IPS*			.037
Less than 4 mg/dL	49	32 (65)
4 mg/dL or more	32	28 (87)
Vasopressor use at IPS*			.017
No	68	47 (69)
Yes	13	13 (100)
Donor			.023
HLA-matched related	37	32 (86)
HLA-mismatched/unrelated	44	28 (64)
Corticosteroids for IPS†			.015
None	10	10 (100)
2 mg/kg/d or less	28	16 (57)
4 mg/kg/d or more	43	34 (79)

Death occurred before or within 30 days of hospital discharge in 81 patients in whom IPS developed after allogeneic HSCT.

Maximum serum creatinine level, total bilirubin level, and vasopressor use within 3 days of IPS onset.

Prednisolone equivalent.

Initiation of mechanical ventilation and renal insufficiency within 3 days of IPS onset remained significant in a multiple logistic regression model.