Multiple Cox regression analysis of idiopathic pneumonia syndrome among allogeneic HSCT recipients after conventional or nonmyeloablative conditioning
Variables . | Hazard ratio (95% CI) . | P . |
|---|---|---|
| Conditioning regimen | .006 | |
| Nonmyeloablative | 1.0 | |
| Conventional | 4.7 (1.5-14) | |
| Patient age | .012 | |
| 40 y and younger | 1.0 | |
| Older than 40 y | 1.8 (1.1-2.9) | |
| Acute GVHD* | .001 | |
| Grades 0-II | 1.0 | |
| Grades III-IV | 2.8 (1.7-4.5) | |
| Underlying diagnosis† | ||
| CML/nonmalignant disease | 1.0 | |
| Acute leukemia/MDS | 1.8 (1.1-3.0) | .030 |
| Other malignancy | 1.8 (0.74-4.4) | .20 |
Variables . | Hazard ratio (95% CI) . | P . |
|---|---|---|
| Conditioning regimen | .006 | |
| Nonmyeloablative | 1.0 | |
| Conventional | 4.7 (1.5-14) | |
| Patient age | .012 | |
| 40 y and younger | 1.0 | |
| Older than 40 y | 1.8 (1.1-2.9) | |
| Acute GVHD* | .001 | |
| Grades 0-II | 1.0 | |
| Grades III-IV | 2.8 (1.7-4.5) | |
| Underlying diagnosis† | ||
| CML/nonmalignant disease | 1.0 | |
| Acute leukemia/MDS | 1.8 (1.1-3.0) | .030 |
| Other malignancy | 1.8 (0.74-4.4) | .20 |
Conventional conditioning (n = 917 patients); nonmyeloablative conditioning (n = 183 patients).
Analysis considered only acute GVHD that preceded the onset of IPS.
Other malignancies included HD, NHL, CLL, and MM and other tumors such as renal cell carcinoma. Nonmalignant diseases included aplastic anemia, immunodeficiencies, and other diseases such as paroxysmal nocturnal hemoglobinuria. See Table 1 footnote for abbreviations.