Molecular characteristics of B-CLPD with 2 or more B-cell clones
. | . | Molecular studies . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|
| . | . | Southern blot . | . | PCR . | . | |||
| Case no. . | Diagnosis . | Pattern of IgH gene rearrangement . | No. of clones . | Pattern of IgH gene rearrangement . | No. of clones . | |||
| 1 | typCLL | RR RG | 2 | RR RG | 2 | |||
| 2 | typCLL | RR RR | 2 | RR RG | 2 | |||
| 3 | typCLL | RR RG | 2 | RR RR | 2 | |||
| 4 | typCLL | RR RG | 2 | RR RG | 2 | |||
| 5 | typCLL | RR RR RG | 3 | RR RG | 2 | |||
| 6 | typCLL | NA | NA | NA | NA | |||
| 7 | typCLL | RR RR | 2 | RR RR | 2 | |||
| 8 | typCLL | RR | 1 | RR RG | 2 | |||
| 9 | typCLL | RR | 1 | RR RR | 2 | |||
| 10 | typCLL | RR | 1 | RR RR | 2 | |||
| 11 | typCLL | RR RR | 2 | RR RG | 2 | |||
| 12 | typCLL | RR RG | 2 | RR RR | 2 | |||
| 13 | typCLL | RR RG | 2 | RR | 1 | |||
| 14 | typCLL | NA | NA | RR RG | 2 | |||
| 15 | typCLL | RR | 1 | RR RR | 2 | |||
| 16 | typCLL | NA | NA | RR RR | 2 | |||
| 17 | typCLL | NA | NA | RR RG | 2 | |||
| 18 | typCLL | NA | NA | RR RG | 2 | |||
| 19 | typCLL | NA | NA | RR RG | 2 | |||
| 20 | typCLL | NA | NA | RG RG | 2 | |||
| 21 | typCLL | NA | NA | RR RG | 2 | |||
| 22 | typCLL | NA | NA | RR RR | 2 | |||
| 23 | typCLL | NA | NA | NA | NA | |||
| 24 | typCLL | NA | NA | NA | NA | |||
| 25 | atypCLL | RR | 1 | RR RG | 2 | |||
| 26 | atypCLL | RR RG | 2 | RR | 1 | |||
| 27 | atypCLL | NA | NA | NA | NA | |||
| 28 | atypCLL | RR RR | 2 | RR RR | 2 | |||
| 29 | atypCLL | RR RR | 2 | RR RR RR | 3 | |||
| 30 | atypCLL | RR | 1 | RR RG | 2 | |||
| 31 | atypCLL | NA | NA | RR RR | 2 | |||
| 32 | atypCLL | RR | 1 | RR RG | 2 | |||
| 33 | atypCLL | NA | NA | NA | NA | |||
| 34 | HCL | RR RG | 2 | NA | NA | |||
| 35 | HCL | NA | NA | NA | NA | |||
| 36 | HCL | NA | NA | RR RR | 2 | |||
| 37 | HCL | NA | NA | RR RG | 2 | |||
| 38 | LPL | NA | NA | RR RG | 2 | |||
| 39 | LPL | RR | 1 | RR RR | 2 | |||
| 40 | LPL | NA | NA | NA | NA | |||
| 41 | LPL | NA | NA | RR RG | 2 | |||
| 42 | SMZL | RR | 1 | RR RR | 2 | |||
| 43 | SMZL | NA | NA | RR RG | 2 | |||
| 44 | SMZL | NA | NA | NA | NA | |||
| 45 | FL | NA | NA | NA | NA | |||
| 46 | FL | RR RR | 2 | RR RG | 2 | |||
| 47 | FL | GG | 0 | RR RR | 2 | |||
| 48 | MCL | RR RR | 2 | RR | 1 | |||
| 49 | MCL | RR RR RR | 3 | RR RR | 2 | |||
| 50 | LCL | RR RR | 2 | RR | 1 | |||
| 51 | LCL | RG | 1 | RR RR | 2 | |||
| 52 | Unclassifiable | RR RR | 2 | RR RG | 2 | |||
| 53 | Unclassifiable | RR | 1 | RR RG | 2 | |||
. | . | Molecular studies . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|
| . | . | Southern blot . | . | PCR . | . | |||
| Case no. . | Diagnosis . | Pattern of IgH gene rearrangement . | No. of clones . | Pattern of IgH gene rearrangement . | No. of clones . | |||
| 1 | typCLL | RR RG | 2 | RR RG | 2 | |||
| 2 | typCLL | RR RR | 2 | RR RG | 2 | |||
| 3 | typCLL | RR RG | 2 | RR RR | 2 | |||
| 4 | typCLL | RR RG | 2 | RR RG | 2 | |||
| 5 | typCLL | RR RR RG | 3 | RR RG | 2 | |||
| 6 | typCLL | NA | NA | NA | NA | |||
| 7 | typCLL | RR RR | 2 | RR RR | 2 | |||
| 8 | typCLL | RR | 1 | RR RG | 2 | |||
| 9 | typCLL | RR | 1 | RR RR | 2 | |||
| 10 | typCLL | RR | 1 | RR RR | 2 | |||
| 11 | typCLL | RR RR | 2 | RR RG | 2 | |||
| 12 | typCLL | RR RG | 2 | RR RR | 2 | |||
| 13 | typCLL | RR RG | 2 | RR | 1 | |||
| 14 | typCLL | NA | NA | RR RG | 2 | |||
| 15 | typCLL | RR | 1 | RR RR | 2 | |||
| 16 | typCLL | NA | NA | RR RR | 2 | |||
| 17 | typCLL | NA | NA | RR RG | 2 | |||
| 18 | typCLL | NA | NA | RR RG | 2 | |||
| 19 | typCLL | NA | NA | RR RG | 2 | |||
| 20 | typCLL | NA | NA | RG RG | 2 | |||
| 21 | typCLL | NA | NA | RR RG | 2 | |||
| 22 | typCLL | NA | NA | RR RR | 2 | |||
| 23 | typCLL | NA | NA | NA | NA | |||
| 24 | typCLL | NA | NA | NA | NA | |||
| 25 | atypCLL | RR | 1 | RR RG | 2 | |||
| 26 | atypCLL | RR RG | 2 | RR | 1 | |||
| 27 | atypCLL | NA | NA | NA | NA | |||
| 28 | atypCLL | RR RR | 2 | RR RR | 2 | |||
| 29 | atypCLL | RR RR | 2 | RR RR RR | 3 | |||
| 30 | atypCLL | RR | 1 | RR RG | 2 | |||
| 31 | atypCLL | NA | NA | RR RR | 2 | |||
| 32 | atypCLL | RR | 1 | RR RG | 2 | |||
| 33 | atypCLL | NA | NA | NA | NA | |||
| 34 | HCL | RR RG | 2 | NA | NA | |||
| 35 | HCL | NA | NA | NA | NA | |||
| 36 | HCL | NA | NA | RR RR | 2 | |||
| 37 | HCL | NA | NA | RR RG | 2 | |||
| 38 | LPL | NA | NA | RR RG | 2 | |||
| 39 | LPL | RR | 1 | RR RR | 2 | |||
| 40 | LPL | NA | NA | NA | NA | |||
| 41 | LPL | NA | NA | RR RG | 2 | |||
| 42 | SMZL | RR | 1 | RR RR | 2 | |||
| 43 | SMZL | NA | NA | RR RG | 2 | |||
| 44 | SMZL | NA | NA | NA | NA | |||
| 45 | FL | NA | NA | NA | NA | |||
| 46 | FL | RR RR | 2 | RR RG | 2 | |||
| 47 | FL | GG | 0 | RR RR | 2 | |||
| 48 | MCL | RR RR | 2 | RR | 1 | |||
| 49 | MCL | RR RR RR | 3 | RR RR | 2 | |||
| 50 | LCL | RR RR | 2 | RR | 1 | |||
| 51 | LCL | RG | 1 | RR RR | 2 | |||
| 52 | Unclassifiable | RR RR | 2 | RR RG | 2 | |||
| 53 | Unclassifiable | RR | 1 | RR RG | 2 | |||
typCLL indicates typical chronic lymphocytic leukemia/small lymphocytic lymphoma; R, rearranged allele; G, germinal configuration; NA, not analyzed; atyp CLL, atypical CLL/small lymphocytic lymphoma; HCL, hairy cell leukemia; LPL, lymphoplasmacytic lymphoma; SMZL, splenic marginal zone lymphoma; FL, follicular lymphoma; MCL, mantle cell lymphoma; and LCL, large cell lymphoma.